| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA desaturase 1 |
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| Ligand | BDBM50304943 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_606657 (CHEMBL1071884) |
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| IC50 | 2±n/a nM |
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| Citation |  Uto, Y; Ogata, T; Kiyotsuka, Y; Ueno, Y; Miyazawa, Y; Kurata, H; Deguchi, T; Watanabe, N; Konishi, M; Okuyama, R; Kurikawa, N; Takagi, T; Wakimoto, S; Ohsumi, J Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats. Bioorg Med Chem Lett20:341-5 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA desaturase 1 |
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| Name: | Acyl-CoA desaturase 1 |
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| Synonyms: | ACOD1_MOUSE | Scd1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41064.54 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1462109 |
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| Residue: | 355 |
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| Sequence: | MPAHMLQEISSSYTTTTTITAPPSGNEREKVKTVPLHLEEDIRPEMKEDIHDPTYQDEEG
PPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIFYYMTSALGITAGAHRLWS
HRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGW
LLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVN
SLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHTF
PFDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKATVLARIKRTGDGSHKSS
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| BDBM50304943 |
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| n/a |
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| Name | BDBM50304943 |
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| Synonyms: | CHEMBL590374 | N-(2-hydroxy-2-phenylethyl)-6-(4-(2-(trifluoromethyl)benzoyl)piperidin-1-yl)pyridazine-3-carboxamideydroxy-2-phenylethyl)-6-(4-(3-(trifluoromethyl)benzoyl)piperidin-1-yl)pyridazine-3-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25F3N4O3 |
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| Mol. Mass. | 498.4969 |
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| SMILES | OC(CNC(=O)c1ccc(nn1)N1CCC(CC1)C(=O)c1ccccc1C(F)(F)F)c1ccccc1 |
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| Structure | 
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