| Reaction Details |
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 | Report a problem with these data |
| Target | Voltage-dependent calcium channel alpha-2 delta subunit |
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| Ligand | BDBM50305900 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_605315 (CHEMBL1071340) |
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| IC50 | 19±n/a nM |
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| Citation |  Blakemore, DC; Bryans, JS; Carnell, P; Carr, CL; Chessum, NE; Field, MJ; Kinsella, N; Osborne, SA; Warren, AN; Williams, SC Synthesis and in vivo evaluation of bicyclic gababutins. Bioorg Med Chem Lett20:461-4 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Voltage-dependent calcium channel alpha-2 delta subunit |
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| Name: | Voltage-dependent calcium channel alpha-2 delta subunit |
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| Synonyms: | Voltage-dependent calcium channel alpha2delta subunit |
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| Type: | PROTEIN |
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| Mol. Mass.: | 123127.66 |
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| Organism: | Sus scrofa |
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| Description: | ChEMBL_605546 |
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| Residue: | 1091 |
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| Sequence: | MAAGCLLALTLTLFQSLLIGPSSQEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDI
YEKYQDLYTVEPNNARQLVEIAARDIEKLLSNRSKALVRLALEAEKVQAAHQWREDFASN
EVVYYNAKDDLDPEKNDSEPGSQRIKPVFIDDANFGRQISYQHAAVHIPTDIYEGSTIVL
NELNWTSALDEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRR
RPWYIQGAASPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQD
VSCFQHLVQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRANCNKIIML
FTDGGEERAQEIFAKYNKDKKVRVFTFSVGQHNYDRGPIQWMACENKGYYYEIPSIGAIR
INTQEYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITGTLPVFNITGQNENKTNLK
NQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKNPKSQEPVTL
DFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTPVNGTDYSL
ALVLPTYSFYYIKAKIEETITQARSKKGKMKDSETLKPDNFEESGYTFIAPRDYCNDLKI
SDNNTEFLLNFNEFIDRKTPNNPSCNTDLINRVLLDAGFTNELVQNYWSKQKNIKGVKAR
FVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYFNKSGPGAYESGI
MVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIRDPCAGPVCDCKRNSDVMDCVI
LDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHLVNISVYAFNKSYDYQSVCEPGAAPKQ
GAGHRSAYVPSIADILHIGWWATAAAWSILQQFLLSLTFPRLLEAVEMEDDDFTASLSKQ
SCITEQTQYFFDNDSKSFSGVLDCGNCSRIFHVEKLMNTNLIFIMVESKGTCPCDTRLLI
QAEQTSDGPDPCDMVKQPRYRKGPDVCFDNNALEDYTDCGGVSGLNPSLWSIFGIQCVLL
WLLSGSRHYQL
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| BDBM50305900 |
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| n/a |
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| Name | BDBM50305900 |
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| Synonyms: | (+)-2-((1S,5S,6R)-6-(aminomethyl)bicyclo[3.2.0]heptan-6-yl)acetic acid | CHEMBL594447 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H17NO2 |
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| Mol. Mass. | 183.2475 |
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| SMILES | NC[C@@]1(CC(O)=O)C[C@@H]2CCC[C@H]12 |r| |
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| Structure | 
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