| Reaction Details |
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 | Report a problem with these data |
| Target | Acyl-CoA desaturase 1 |
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| Ligand | BDBM50306126 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_606059 (CHEMBL1071958) |
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| IC50 | 0.28±n/a nM |
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| Citation |  Uto, Y; Kiyotsuka, Y; Ueno, Y; Miyazawa, Y; Kurata, H; Ogata, T; Deguchi, T; Yamada, M; Watanabe, N; Konishi, M; Kurikawa, N; Takagi, T; Wakimoto, S; Kono, K; Ohsumi, J Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4'-piperidine]. Bioorg Med Chem Lett20:746-54 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acyl-CoA desaturase 1 |
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| Name: | Acyl-CoA desaturase 1 |
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| Synonyms: | ACOD1_MOUSE | Scd1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41064.54 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1462109 |
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| Residue: | 355 |
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| Sequence: | MPAHMLQEISSSYTTTTTITAPPSGNEREKVKTVPLHLEEDIRPEMKEDIHDPTYQDEEG
PPPKLEYVWRNIILMVLLHLGGLYGIILVPSCKLYTCLFGIFYYMTSALGITAGAHRLWS
HRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGW
LLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVN
SLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHTF
PFDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKATVLARIKRTGDGSHKSS
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| BDBM50306126 |
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| n/a |
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| Name | BDBM50306126 |
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| Synonyms: | CHEMBL605412 | N-(2-hydroxy-2-(pyridin-3-yl)ethyl)-6-(5-(trifluoromethyl)spiro[chroman-2,4'-piperidine]-1'-yl)pyridazine-3-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26F3N5O3 |
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| Mol. Mass. | 513.5115 |
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| SMILES | OC(CNC(=O)c1ccc(nn1)N1CCC2(CC1)CCc1c(O2)cccc1C(F)(F)F)c1cccnc1 |
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| Structure | 
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