Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50306412 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_609881 (CHEMBL1073437) | ||
IC50 | 1.1±n/a nM | ||
Citation | Tice, CM; Zhao, W; Xu, Z; Cacatian, ST; Simpson, RD; Ye, YJ; Singh, SB; McKeever, BM; Lindblom, P; Guo, J; Krosky, PM; Kruk, BA; Berbaum, J; Harrison, RK; Johnson, JJ; Bukhtiyarov, Y; Panemangalore, R; Scott, BB; Zhao, Y; Bruno, JG; Zhuang, L; McGeehan, GM; He, W; Claremon, DA Spirocyclic ureas: orally bioavailable 11beta-HSD1 inhibitors identified by computer-aided drug design. Bioorg Med Chem Lett20:881-6 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM50306412 | |||
n/a | |||
Name | BDBM50306412 | ||
Synonyms: | 4-Benzyl-piperidine-1-carboxylic acid adamantan-2-ylamide | CHEMBL603885 | ||
Type | Small organic molecule | ||
Emp. Form. | C23H32N2O | ||
Mol. Mass. | 352.513 | ||
SMILES | O=C(NC1C2CC3CC(C2)CC1C3)N1CCC(Cc2ccccc2)CC1 |TLB:9:8:12:5.4.3,9:4:7.8.10:12,THB:3:4:7:10.11.12,3:11:7:5.9.4,2:3:7.8.10:12,(-3.99,-11.29,;-3.95,-9.75,;-5.26,-8.94,;-6.61,-9.68,;-6.62,-11.2,;-8.02,-11.55,;-9.34,-11.06,;-10.54,-12.34,;-9.04,-11.92,;-7.64,-12.48,;-9.05,-10.32,;-8.01,-9.1,;-9.36,-9.57,;-2.59,-9.01,;-1.29,-9.82,;.06,-9.1,;.11,-7.56,;1.47,-6.83,;2.78,-7.64,;2.72,-9.17,;4.03,-9.98,;5.39,-9.25,;5.43,-7.71,;4.12,-6.9,;-1.2,-6.75,;-2.56,-7.48,)| | ||
Structure |