Reaction Details | |||
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Target | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Ligand | BDBM50222205 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_609376 (CHEMBL1072762) | ||
IC50 | 810±n/a nM | ||
Citation | Rollinger, JM; Kratschmar, DV; Schuster, D; Pfisterer, PH; Gumy, C; Aubry, EM; Brandstötter, S; Stuppner, H; Wolber, G; Odermatt, A 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches. Bioorg Med Chem18:1507-15 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
11-beta-hydroxysteroid dehydrogenase 1 | |||
Name: | 11-beta-hydroxysteroid dehydrogenase 1 | ||
Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 | ||
Type: | Enzyme | ||
Mol. Mass.: | 32409.16 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28845 | ||
Residue: | 292 | ||
Sequence: |
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BDBM50222205 | |||
n/a | |||
Name | BDBM50222205 | ||
Synonyms: | (1S,2R,4aS,6aS,6bR,8aR,10R,11R,12aR,12bR,14bS)-10,11-dihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid | 2-alpha-hydroxyursolic acid | 2alpha,2beta-dihydroxy-18beta-ursan-12-ene-28-oic acid | 2alpha,3beta-Dihydroxyurs-12-en-28-oic Acid | CHEMBL391533 | Corosolic acid | US11660306, Example Corosolic acid | ||
Type | Small organic molecule | ||
Emp. Form. | C30H48O4 | ||
Mol. Mass. | 472.6997 | ||
SMILES | C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2[C@H]1C)C(O)=O |r,c:9| | ||
Structure |