| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor IX |
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| Ligand | BDBM50307275 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_610620 (CHEMBL1069634) |
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| Ki | 11±n/a nM |
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| Citation |  Wang, S; Beck, R; Burd, A; Blench, T; Marlin, F; Ayele, T; Buxton, S; Dagostin, C; Malic, M; Joshi, R; Barry, J; Sajad, M; Cheung, C; Shaikh, S; Chahwala, S; Chander, C; Baumgartner, C; Holthoff, HP; Murray, E; Blackney, M; Giddings, A Structure based drug design: development of potent and selective factor IXa (FIXa) inhibitors. J Med Chem53:1473-82 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor IX |
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| Name: | Coagulation factor IX |
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| Synonyms: | Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component |
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| Type: | Enzyme |
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| Mol. Mass.: | 51768.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00740 |
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| Residue: | 461 |
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| Sequence: | MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
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| BDBM50307275 |
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| n/a |
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| Name | BDBM50307275 |
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| Synonyms: | CHEMBL601231 | {4-[2-(2-Carbamimidoyl-benzo[b]thiophen-4-yloxy)-2-phenylethoxycarbonylamino]-3,5-dimethyl-pyrazol-1-yl}-acetic acid ethyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27N5O5S |
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| Mol. Mass. | 521.588 |
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| SMILES | COC(=O)Cn1nc(C)c(NC(=O)OCC(Oc2cccc3sc(cc23)C(N)=N)c2ccccc2)c1C |
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| Structure | 
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