| Reaction Details |
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 | Report a problem with these data |
| Target | Coagulation factor X |
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| Ligand | BDBM50307289 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_610619 (CHEMBL1069633) |
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| Ki | 52±n/a nM |
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| Citation |  Wang, S; Beck, R; Burd, A; Blench, T; Marlin, F; Ayele, T; Buxton, S; Dagostin, C; Malic, M; Joshi, R; Barry, J; Sajad, M; Cheung, C; Shaikh, S; Chahwala, S; Chander, C; Baumgartner, C; Holthoff, HP; Murray, E; Blackney, M; Giddings, A Structure based drug design: development of potent and selective factor IXa (FIXa) inhibitors. J Med Chem53:1473-82 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coagulation factor X |
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| Name: | Coagulation factor X |
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| Synonyms: | Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor |
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| Type: | Enzyme |
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| Mol. Mass.: | 54726.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 488 |
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| Sequence: | MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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| BDBM50307289 |
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| n/a |
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| Name | BDBM50307289 |
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| Synonyms: | 2-(2-Carbamimidoyl-benzo[b]thiophen-4-yloxy)-N-(4-methoxy-phenyl)-2-phenylacetamide | CHEMBL596948 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21N3O3S |
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| Mol. Mass. | 431.507 |
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| SMILES | COc1ccc(NC(=O)C(Oc2cccc3sc(cc23)C(N)=N)c2ccccc2)cc1 |
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| Structure | 
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