| Reaction Details |
|---|
 | Report a problem with these data |
| Target | MAP kinase-interacting serine/threonine-protein kinase 2 |
|---|
| Ligand | BDBM50307507 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_612006 (CHEMBL1072213) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Traquandi, G; Ciomei, M; Ballinari, D; Casale, E; Colombo, N; Croci, V; Fiorentini, F; Isacchi, A; Longo, A; Mercurio, C; Panzeri, A; Pastori, W; Pevarello, P; Volpi, D; Roussel, P; Vulpetti, A; Brasca, MG Identification of potent pyrazolo[4,3-h]quinazoline-3-carboxamides as multi-cyclin-dependent kinase inhibitors. J Med Chem53:2171-87 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| MAP kinase-interacting serine/threonine-protein kinase 2 |
|---|
| Name: | MAP kinase-interacting serine/threonine-protein kinase 2 |
|---|
| Synonyms: | GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 51870.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9HBH9 |
|---|
| Residue: | 465 |
|---|
| Sequence: | MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAK
KRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPG
HIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNEL
EASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCS
PISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCG
SDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAA
QVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAG
QGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
|
|
|
|---|
| BDBM50307507 |
|---|
| n/a |
|---|
| Name | BDBM50307507 |
|---|
| Synonyms: | CHEMBL597754 | N-1-Dimethyl-8-{[1-(methylsulfonyl)piperidin-4-yl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H34N8O4S |
|---|
| Mol. Mass. | 530.643 |
|---|
| SMILES | CNC(=O)c1nn(C)c-2c1CCc1cnc(NC3CCN(CC3)C(=O)C3CCN(CC3)S(C)(=O)=O)nc-21 |
|---|
| Structure | 
|
|---|
Search and Browse
