Reaction Details |
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Target | Histone deacetylase 8 |
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Ligand | BDBM50308307 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_613847 (CHEMBL1067670) |
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IC50 | 1060±n/a nM |
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Citation | Zhang, Y; Feng, J; Liu, C; Zhang, L; Jiao, J; Fang, H; Su, L; Zhang, X; Zhang, J; Li, M; Wang, B; Xu, W Design, synthesis and preliminary activity assay of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as novel Histone deacetylases (HDACs) inhibitors. Bioorg Med Chem18:1761-72 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 8 |
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Name: | Histone deacetylase 8 |
Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
Type: | Enzyme |
Mol. Mass.: | 41749.60 |
Organism: | Homo sapiens (Human) |
Description: | Q9BY41 |
Residue: | 377 |
Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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BDBM50308307 |
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n/a |
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Name | BDBM50308307 |
Synonyms: | (S)-7-(2-(Hydroxyamino)-2-oxoethoxy)-N-(naphthalen-1-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide hydrochloride | CHEMBL597999 |
Type | Small organic molecule |
Emp. Form. | C22H21N3O4 |
Mol. Mass. | 391.4198 |
SMILES | ONC(=O)COc1ccc2C[C@H](NCc2c1)C(=O)Nc1cccc2ccccc12 |r| |
Structure |
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