| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium/glucose cotransporter 2 |
|---|
| Ligand | BDBM50308535 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_613466 (CHEMBL1070174) |
|---|
| IC50 | 12000±n/a nM |
|---|
| Citation |  Arai, H; Hirasawa, Y; Rahman, A; Kusumawati, I; Zaini, NC; Sato, S; Aoyama, C; Takeo, J; Morita, H Alstiphyllanines E-H, picraline and ajmaline-type alkaloids from Alstonia macrophylla inhibiting sodium glucose cotransporter. Bioorg Med Chem18:2152-8 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium/glucose cotransporter 2 |
|---|
| Name: | Sodium/glucose cotransporter 2 |
|---|
| Synonyms: | Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 72902.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P31639 |
|---|
| Residue: | 672 |
|---|
| Sequence: | MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA
|
|
|
|---|
| BDBM50308535 |
|---|
| n/a |
|---|
| Name | BDBM50308535 |
|---|
| Synonyms: | CHEMBL601712 | methyl (14E)-14-ethylidene-6-methoxy-2-methyl-19-[(propanoyloxy)methyl]-18-oxa-2,12-diazahexacyclo[9.6.1.1^{9,15}.0^{1,9}.0^{3,8}.0^{12,17}]nonadeca-3(8),4,6-triene-19-carboxylate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H32N2O6 |
|---|
| Mol. Mass. | 468.5421 |
|---|
| SMILES | CCC(=O)OC[C@]1([C@H]2C[C@@H]3N(C\C2=C\C)[C@@H]2C[C@]11c4cc(OC)ccc4N(C)[C@]31O2)C(=O)OC |r| |
|---|
| Structure | 
|
|---|
Search and Browse
