| Reaction Details |
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 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Ligand | BDBM50233538 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_607151 (CHEMBL1064823) |
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| IC50 | 90±n/a nM |
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| Citation |  Beseda, I; Czollner, L; Shah, PS; Khunt, R; Gaware, R; Kosma, P; Stanetty, C; Del Ruiz-Ruiz, MC; Amer, H; Mereiter, K; Da Cunha, T; Odermatt, A; Classen-Houben, D; Jordis, U Synthesis of glycyrrhetinic acid derivatives for the treatment of metabolic diseases. Bioorg Med Chem18:433-54 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 11-beta-hydroxysteroid dehydrogenase 1 |
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| Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
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| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_RAT | Hsd11 | Hsd11b1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 31889.48 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | P16232 |
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| Residue: | 288 |
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| Sequence: | MKKYLLPVLVLCLGYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLT
ARSEEGLQKVVSRCLELGAASAHYIAGTMEDMAFAERFVVEAGKLLGGLDMLILNHITQT
TMSLFHDDIHSVRRSMEVNFLSYVVLSTAALPMLKQSNGSIAIISSMAGKMTQPLIASYS
ASKFALDGFFSTIRKEHLMTKVNVSITLCVLGFIDTETALKETSGIILSQAAPKEECALE
IIKGTVLRKDEVYYDKSSWTPLLLGNPGRRIMEFLSLRSYNRDLFVSN
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| BDBM50233538 |
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| n/a |
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| Name | BDBM50233538 |
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| Synonyms: | 18beta-glycyrrhetic acid | 3beta-hydroxy-11-oxoolean-12-en-30-oic acid | CHEMBL230006 | US11660306, Example 18beta Glycyrrhetinic acid | glycyrrhetinic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C30H46O4 |
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| Mol. Mass. | 470.6838 |
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| SMILES | CC1(C)[C@@H](O)CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C(O)=O |r,t:19| |
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| Structure | 
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