| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A2a |
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| Ligand | BDBM50309495 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_609496 (CHEMBL1071768) |
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| Ki | 48±n/a nM |
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| Citation |  Beattie, D; Brearley, A; Brown, Z; Charlton, SJ; Cox, B; Fairhurst, RA; Fozard, JR; Gedeck, P; Kirkham, P; Meja, K; Nanson, L; Neef, J; Oakman, H; Spooner, G; Taylor, RJ; Turner, RJ; West, R; Woodward, H Synthesis and evaluation of two series of 4'-aza-carbocyclic nucleosides as adenosine A2A receptor agonists. Bioorg Med Chem Lett20:1219-24 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A2a |
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| Name: | Adenosine receptor A2a |
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| Synonyms: | A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44716.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29274 |
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| Residue: | 412 |
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| Sequence: | MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
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| BDBM50309495 |
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| n/a |
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| Name | BDBM50309495 |
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| Synonyms: | (2S,3S,4R,5R)-2-(4-ethyl-1H-1,2,3-triazol-1-yl)-5-(2-(2-(1-ethyl-1H-imidazol-4-yl)ethylamino)-6-(2-ethylbutylamino)-9H-purin-9-yl)tetrahydrofuran-3,4-diol | CHEMBL599566 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H41N11O2 |
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| Mol. Mass. | 551.6869 |
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| SMILES | CCC(CC)CNc1nc(NCCc2cn(CC)cn2)nc2n(cnc12)[C@@H]1C[C@@H]([C@@H](O)[C@H]1O)n1cc(CC)nn1 |r| |
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| Structure | 
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