| Reaction Details |
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 | Report a problem with these data |
| Target | Phospholipase A-2-activating protein |
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| Ligand | BDBM50309563 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_610122 (CHEMBL1074487) |
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| IC50 | 2200±n/a nM |
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| Citation |  Lanier, M; Sergienko, E; Simão, AM; Su, Y; Chung, T; Millán, JL; Cashman, JR Design and synthesis of selective inhibitors of placental alkaline phosphatase. Bioorg Med Chem18:573-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phospholipase A-2-activating protein |
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| Name: | Phospholipase A-2-activating protein |
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| Synonyms: | PLAA | PLAP | PLAP_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 87154.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_610122 |
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| Residue: | 795 |
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| Sequence: | MTSGATRYRLSCSLRGHELDVRGLVCCAYPPGAFVSVSRDRTTRLWAPDSPNRSFTEMHC
MSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKNTVCSLSS
GKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTVKLWKA
GRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQITGECLEVYYGHTNYIYSISVF
PNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVVGASDGIIRVFTES
EDRTASAEEIKAFEKELSHATIDSKTGDLGDINAEQLPGREHLNEPGTREGQTRLIRDGE
KVEAYQWSVSEGRWIKIGDVVGSSGANQQTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPY
NTSDDPWLTAYNFLQKNDLNPMFLDQVAKFIIDNTKGQMLGLGNPSFSDPFTGGGRYVPG
SSGSSNTLPTADPFTGAGRYVPGSASMGTTMAGVDPFTGNSAYRSAASKTMNIYFPKKEA
VTFDQANPTQILGKLKELNGTAPEEKKLTEDDLILLEKILSLICNSSSEKPTVQQLQILW
KAINCPEDIVFPALDILRLSIKHPSVNENFCNEKEGAQFSSHLINLLNPKGKPANQLLAL
RTFCNCFVGQAGQKLMMSQRESLMSHAIELKSGSNKNIHIALATLALNYSVCFHKDHNIE
GKAQCLSLISTILEVVQDLEATFRLLVALGTLISDDSNAVQLAKSLGVDSQIKKYSSVSE
PAKVSECCRFILNLL
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| BDBM50309563 |
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| n/a |
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| Name | BDBM50309563 |
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| Synonyms: | 2-(2-(3,4-dihydroxyphenyl)-2-oxoethylthio)-4-(methoxymethyl)-6-methylnicotinonitrile | CHEMBL598663 | cid_586278 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H16N2O4S |
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| Mol. Mass. | 344.385 |
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| SMILES | COCc1cc(C)nc(SCC(=O)c2ccc(O)c(O)c2)c1C#N |
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| Structure | 
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