| Reaction Details |
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 | Report a problem with these data |
| Target | Alkaline phosphatase, tissue-nonspecific isozyme |
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| Ligand | BDBM50309567 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_610123 (CHEMBL1074488) |
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| IC50 | 29200±n/a nM |
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| Citation |  Lanier, M; Sergienko, E; Simão, AM; Su, Y; Chung, T; Millán, JL; Cashman, JR Design and synthesis of selective inhibitors of placental alkaline phosphatase. Bioorg Med Chem18:573-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Alkaline phosphatase, tissue-nonspecific isozyme |
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| Name: | Alkaline phosphatase, tissue-nonspecific isozyme |
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| Synonyms: | ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57306.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1448917 |
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| Residue: | 524 |
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| Sequence: | MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
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| BDBM50309567 |
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| n/a |
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| Name | BDBM50309567 |
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| Synonyms: | 3-(2-(3,4-dihydroxyphenyl)-2-oxoethyl)-6,7-dimethoxyisobenzofuran-1(3H)-one | CHEMBL610508 | cid_2940433 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16O7 |
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| Mol. Mass. | 344.3154 |
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| SMILES | COc1ccc2C(CC(=O)c3ccc(O)c(O)c3)OC(=O)c2c1OC |
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| Structure | 
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