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TargetAlkaline phosphatase, tissue-nonspecific isozyme
LigandBDBM41887
Substrate/Competitorn/a
Meas. Tech.ChEMBL_610123 (CHEMBL1074488)
IC50>100000±n/a nM
Citation Lanier, M; Sergienko, E; Simão, AM; Su, Y; Chung, T; Millán, JL; Cashman, JR Design and synthesis of selective inhibitors of placental alkaline phosphatase. Bioorg Med Chem18:573-9 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Alkaline phosphatase, tissue-nonspecific isozyme
Name:Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:PROTEIN
Mol. Mass.:57306.17
Organism:Homo sapiens (Human)
Description:ChEMBL_1448917
Residue:524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM41887
n/a
NameBDBM41887
Synonyms:1-(3,4-dihydroxyphenyl)-2-(1-imidazolyl)ethanone;hydrochloride | 1-(3,4-dihydroxyphenyl)-2-imidazol-1-yl-ethanone;hydrochloride | 1-(3,4-dihydroxyphenyl)-2-imidazol-1-ylethanone;hydrochloride | 1-[3,4-bis(oxidanyl)phenyl]-2-imidazol-1-yl-ethanone;hydrochloride | CHEMBL349641 | MLS-0315813.0002 | cid_25067472 | cid_52780
TypeSmall organic molecule
Emp. Form.C11H10N2O3
Mol. Mass.218.2087
SMILESOc1ccc(cc1O)C(=O)Cn1ccnc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: