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TargetAlkaline phosphatase, germ cell type
LigandBDBM41890
Substrate/Competitorn/a
Meas. Tech.ChEMBL_610126 (CHEMBL1074491)
IC50 2700±n/a nM
Citation Lanier, M; Sergienko, E; Simão, AM; Su, Y; Chung, T; Millán, JL; Cashman, JR Design and synthesis of selective inhibitors of placental alkaline phosphatase. Bioorg Med Chem18:573-9 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Alkaline phosphatase, germ cell type
Name:Alkaline phosphatase, germ cell type
Synonyms:ALPG | ALPPL | ALPPL2 | Alkaline phosphatase placental-like | PPBN_HUMAN | placental-like alkaline phosphatase preproprotein
Type:PROTEIN
Mol. Mass.:57374.31
Organism:Homo sapiens (Human)
Description:ChEMBL_29964
Residue:532
Sequence:
MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLG
DGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLC
GVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYA
HTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDY
SQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRD
STLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERA
GQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVL
KDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHV
MAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM41890
n/a
NameBDBM41890
Synonyms:2-(1-benzimidazolyl)-1-(3,4-dihydroxyphenyl)ethanone;hydrochloride | 2-(benzimidazol-1-yl)-1-(3,4-dihydroxyphenyl)ethanone;hydrochloride | 2-(benzimidazol-1-yl)-1-[3,4-bis(oxidanyl)phenyl]ethanone;hydrochloride | CHEMBL608723 | MLS-0315853.0001 | cid_25067493
TypeSmall organic molecule
Emp. Form.C15H12N2O3
Mol. Mass.268.2674
SMILESOc1ccc(cc1O)C(=O)Cn1cnc2ccccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: