| Reaction Details |
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 | Report a problem with these data |
| Target | Dipeptidyl peptidase 1 |
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| Ligand | BDBM50310689 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_621086 (CHEMBL1113170) |
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| IC50 | 17±n/a nM |
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| Citation |  Guay, D; Beaulieu, C; Truchon, JF; Jagadeeswar Reddy, T; Zamboni, R; Bayly, CI; Methot, N; Rubin, J; Ethier, D; David Percival, M Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C. Bioorg Med Chem Lett19:5392-6 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dipeptidyl peptidase 1 |
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| Name: | Dipeptidyl peptidase 1 |
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| Synonyms: | CATC_HUMAN | CPPI | CTSC | Cathepsin C | Cathepsin J | Dipeptidyl peptidase 1 (DDPI) | Dipeptidyl peptidase 1 (DPPI) | Dipeptidyl peptidase I | Dipeptidyl peptidase I (DPPI) |
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| Type: | Enzyme |
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| Mol. Mass.: | 51857.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P53634 |
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| Residue: | 463 |
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| Sequence: | MGAGPSLLLAALLLLLSGDGAVRCDTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQ
EKKVVVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAFFKYKEEGSKVTTYCNE
TMTGWVHDVLGRNWACFTGKKVGTASENVYVNIAHLKNSQEKYSNRLYKYDHNFVKAINA
IQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLTAEIQQKILHLPTSWDWRNV
HGINFVSPVRNQASCGSCYSFASMGMLEARIRILTNNSQTPILSPQEVVSCSQYAQGCEG
GFPYLIAGKYAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGGFYGGCNEALM
KLELVHHGPMAVAFEVYDDFLHYKKGIYHHTGLRDPFNPFELTNHAVLLVGYGTDSASGM
DYWIVKNSWGTGWGENGYFRIRRGTDECAIESIAVAATPIPKL
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| BDBM50310689 |
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| n/a |
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| Name | BDBM50310689 |
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| Synonyms: | CHEMBL1080786 | cis-(S)-2-amino-N-((1S,2S)-1-cyano-2-phenylcyclopropyl)-3-(thiophen-2-yl)propanamide |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17N3OS |
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| Mol. Mass. | 311.401 |
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| SMILES | N[C@@H](Cc1cccs1)C(=O)N[C@]1(C[C@H]1c1ccccc1)C#N |r| |
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| Structure | 
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