| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein phosphatase non-receptor type 1 |
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| Ligand | BDBM50311429 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_622615 (CHEMBL1109327) |
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| IC50 | 52400±n/a nM |
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| Citation |  Kumar, A; Maurya, RA; Sharma, S; Ahmad, P; Singh, AB; Bhatia, G; Srivastava, AK Pyranocoumarins: a new class of anti-hyperglycemic and anti-dyslipidemic agents. Bioorg Med Chem Lett19:6447-51 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein phosphatase non-receptor type 1 |
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| Name: | Tyrosine-protein phosphatase non-receptor type 1 |
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| Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
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| Type: | Protein phosphatase |
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| Mol. Mass.: | 49963.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Human recombinant GST-fusion PTP1B (1-435). |
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| Residue: | 435 |
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| Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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| BDBM50311429 |
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| n/a |
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| Name | BDBM50311429 |
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| Synonyms: | 9-Hydroxymethyl-4-methyl-9-morpholin-4-ylmethyl-8, 9-dihydro-pyrano[2,3-f]chromene-2,10-dione | CHEMBL1077922 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21NO6 |
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| Mol. Mass. | 359.3731 |
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| SMILES | Cc1cc(=O)oc2c3C(=O)C(CO)(CN4CCOCC4)COc3ccc12 |
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| Structure | 
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