| Reaction Details |
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 | Report a problem with these data |
| Target | Casein kinase I isoform gamma-1 |
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| Ligand | BDBM50311954 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_619947 (CHEMBL1113989) |
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| IC50 | >50000±n/a nM |
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| Citation |  Shim, J; Eid, C; Lee, J; Liu, E; Chaudhary, D; Boschelli, DH Synthesis and PKCtheta inhibitory activity of a series of 5-vinyl phenyl sulfonamide-3-pyridinecarbonitriles. Bioorg Med Chem Lett19:6575-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Casein kinase I isoform gamma-1 |
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| Name: | Casein kinase I isoform gamma-1 |
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| Synonyms: | CKI-gamma 1 | CSNK1G1 | Casein kinase I | Casein kinase I gamma 1 isoform | Casein kinase I isoform gamma-1 | KC1G1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48530.93 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774608 |
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| Residue: | 422 |
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| Sequence: | MDHPSREKDERQRTTKPMAQRSAHCSRPSGSSSSSGVLMVGPNFRVGKKIGCGNFGELRL
GKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAGEGLPQVYYFGPCGKYNAMVLEL
LGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQGNKKE
HVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHM
FMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPIEALCENFPEEMATYLRYVRRLDFFE
KPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSGASAITRESHTHRDRP
SQQQPLRNQVVSSTNGELNVDDPTGAHSNAPITAHAEVEVVEEAKCCCFFKRKRKKTAQR
HK
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| BDBM50311954 |
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| n/a |
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| Name | BDBM50311954 |
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| Synonyms: | 6-methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpiperazin-1-ylsulfonyl)styryl)nicotinonitrile | CHEMBL1080995 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H30N6O2S |
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| Mol. Mass. | 526.653 |
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| SMILES | CN1CCN(CC1)S(=O)(=O)c1cccc(\C=C\c2c(C)ncc(C#N)c2Nc2ccc3[nH]ccc3c2C)c1 |
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| Structure | 
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