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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Serine/threonine-protein kinase B-raf | ||
| Ligand | BDBM50311982 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_620206 (CHEMBL1115841) | ||
| IC50 | 1.5±n/a nM | ||
| Citation |  Wang, X; Berger, DM; Salaski, EJ; Torres, N; Hu, Y; Levin, JI; Powell, D; Wojciechowicz, D; Collins, K; Frommer, E Discovery of highly potent and selective type I B-Raf kinase inhibitors. Bioorg Med Chem Lett19:6571-4 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Serine/threonine-protein kinase B-raf | |||
| Name: | Serine/threonine-protein kinase B-raf | ||
| Synonyms: | B-RAF | B-Raf Protein Kinase | B-Raf proto-oncogene serine/threonine-protein kinase | BRAF | BRAF1 | BRAF_HUMAN | RAFB1 | p94 | v-Raf murine sarcoma viral oncogene homolog B1 | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 84446.00 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P15056 | ||
| Residue: | 766 | ||
| Sequence: |
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| BDBM50311982 | |||
| n/a | |||
| Name | BDBM50311982 | ||
| Synonyms: | (S)-3-(2-(pyridin-4-yl)-7-(4-(quinuclidin-3-ylamino)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)phenol | CHEMBL1087510 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H28N6O | ||
| Mol. Mass. | 488.5829 | ||
| SMILES | Oc1cccc(c1)-c1c(nn2c(ccnc12)-c1ccc(N[C@@H]2CN3CCC2CC3)cc1)-c1ccncc1 |r,wD:21.23,(12.65,-48.79,;13.43,-47.46,;14.97,-47.48,;15.75,-46.14,;14.99,-44.81,;13.46,-44.8,;12.67,-46.12,;12.72,-43.45,;13.63,-42.21,;12.73,-40.96,;11.26,-41.43,;9.93,-40.66,;8.59,-41.43,;8.59,-42.96,;9.92,-43.74,;11.26,-42.97,;9.93,-39.13,;8.6,-38.36,;8.6,-36.81,;9.93,-36.04,;9.95,-34.5,;11.3,-33.75,;11.33,-32.2,;12.68,-31.45,;14,-32.25,;13.98,-33.79,;12.63,-34.54,;13.14,-33.23,;11.85,-32.65,;11.27,-36.81,;11.28,-38.36,;15.17,-42.22,;15.93,-43.56,;17.47,-43.57,;18.25,-42.24,;17.47,-40.9,;15.94,-40.9,)| | ||
| Structure | 
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