Reaction Details |
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Target | Low molecular weight protein-tyrosine phosphatase A |
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Ligand | BDBM50312226 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_621991 (CHEMBL1106782) |
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Ki | >100000±n/a nM |
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Citation | Rawls, KA; Lang, PT; Takeuchi, J; Imamura, S; Baguley, TD; Grundner, C; Alber, T; Ellman, JA Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA. Bioorg Med Chem Lett19:6851-4 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Low molecular weight protein-tyrosine phosphatase A |
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Name: | Low molecular weight protein-tyrosine phosphatase A |
Synonyms: | PTPA_MYCTU | PTPase | Probable low molecular weight protein-tyrosine-phosphatase | Protein Tyrosine Phosphatase PTPA | mptpA | ptpA |
Type: | Hydrolase |
Mol. Mass.: | 17891.84 |
Organism: | Mycobacterium tuberculosis |
Description: | n/a |
Residue: | 163 |
Sequence: | MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGTGNWHVGSCADERAAG
VLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEAARVRMLRSFDPRSGTH
ALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS
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BDBM50312226 |
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n/a |
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Name | BDBM50312226 |
Synonyms: | 4-(difluoro(phosphono)methyl)benzoic acid | CHEMBL1081059 |
Type | Small organic molecule |
Emp. Form. | C8H7F2O5P |
Mol. Mass. | 252.1087 |
SMILES | OC(=O)c1ccc(cc1)C(F)(F)P(O)(O)=O |
Structure |
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