| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin E |
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| Ligand | BDBM50312665 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_614704 (CHEMBL1113389) |
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| IC50 | 1710±n/a nM |
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| Citation |  Chou, LC; Chen, CT; Lee, JC; Way, TD; Huang, CH; Huang, SM; Teng, CM; Yamori, T; Wu, TS; Sun, CM; Chien, DS; Qian, K; Morris-Natschke, SL; Lee, KH; Huang, LJ; Kuo, SC Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one monosodium phosphate (CHM-1-P-Na) as a potent antitumor agent. J Med Chem53:1616-26 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin E |
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| Name: | Cathepsin E |
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| Synonyms: | 3.4.23.34 | CATE_HUMAN | CTSE | Cathepsin E form I | Cathepsin E form II |
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| Type: | Enzyme |
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| Mol. Mass.: | 43298.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14091 |
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| Residue: | 396 |
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| Sequence: | MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESC
SMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRF
QPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAE
FDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSH
FSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNA
IGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDI
HPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP
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| BDBM50312665 |
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| n/a |
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| Name | BDBM50312665 |
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| Synonyms: | CHEMBL1088572 | Sodium 2-(2-Fluorophenyl)-6,7-methylenedioxyquinolin-4-yl hydrogen phosphate |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12FNO6P |
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| Mol. Mass. | 364.2423 |
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| SMILES | OP([O-])(=O)OC1CC(=Nc2cc3OCOc3cc12)c1ccccc1F |c:7| |
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| Structure | 
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