| Reaction Details |
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 | Report a problem with these data |
| Target | Cholinesterase |
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| Ligand | BDBM50312817 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_615850 (CHEMBL1101960) |
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| IC50 | 170±n/a nM |
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| Citation |  Takahashi, J; Hijikuro, I; Kihara, T; Murugesh, MG; Fuse, S; Kunimoto, R; Tsumura, Y; Akaike, A; Niidome, T; Okuno, Y; Takahashi, T; Sugimoto, H Design, synthesis, evaluation and QSAR analysis of N(1)-substituted norcymserine derivatives as selective butyrylcholinesterase inhibitors. Bioorg Med Chem Lett20:1718-20 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholinesterase |
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| Name: | Cholinesterase |
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| Synonyms: | Acylcholine acylhydrolase | Bche | Butyrylcholine esterase | Butyrylcholinesterase | CHLE_MOUSE | Choline esterase II | Pseudocholinesterase |
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| Type: | Protein |
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| Mol. Mass.: | 68465.99 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | Q03311 |
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| Residue: | 603 |
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| Sequence: | MQTQHTKVTQTHFLLWILLLCMPFGKSHTEEDFIITTKTGRVRGLSMPVLGGTVTAFLGI
PYAQPPLGSLRFKKPQPLNKWPDIHNATQYANSCYQNIDQAFPGFQGSEMWNPNTNLSED
CLYLNVWIPVPKPKNATVMVWIYGGGFQTGTSSLPVYDGKFLARVERVIVVSMNYRVGAL
GFLAFPGNPDAPGNMGLFDQQLALQWVQRNIAAFGGNPKSITIFGESAGAASVSLHLLCP
QSYPLFTRAILESGSSNAPWAVKHPEEARNRTLTLAKFTGCSKENEMEMIKCLRSKDPQE
ILRNERFVLPSDSILSINFGPTVDGDFLTDMPHTLLQLGKVKKAQILVGVNKDEGTAFLV
YGAPGFSKDNDSLITRKEFQEGLNMYFPGVSRLGKEAVLFYYVDWLGEQSPEVYRDALDD
VIGDYNIICPALEFTKKFAELENNAFFYFFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLG
RRVNYTRAEEIFSRSIMKTWANFAKYGHPNGTQGNSTMWPVFTSTEQKYLTLNTEKSKIY
SKLRAPQCQFWRLFFPKVLEMTGDIDETEQEWKAGFHRWSNYMMDWQNQFNDYTSKKESC
TAL
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| BDBM50312817 |
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| n/a |
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| Name | BDBM50312817 |
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| Synonyms: | (3aS,8aR)-3a,8-dimethyl-1-(2-(pyridin-4-yl)ethyl)-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl 4-isopropylphenylcarbamate | CHEMBL1081428 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H34N4O2 |
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| Mol. Mass. | 470.6059 |
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| SMILES | CC(C)c1ccc(NC(=O)Oc2ccc3N(C)[C@H]4N(CCc5ccncc5)CC[C@@]4(C)c3c2)cc1 |r| |
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| Structure | 
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