| Reaction Details |
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 | Report a problem with these data |
| Target | Opioid receptors; mu & delta |
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| Ligand | BDBM50312854 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_615876 |
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| Ki | 0.96±n/a nM |
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| Citation |  Ballet S; Marczak ED; Feytens D; Salvadori S; Sasaki Y; Abell AD; Lazarus LH; Balboni G; Tourwé D Novel multiple opioid ligands based on 4-aminobenzazepinone (Aba), azepinoindole (Aia) and tetrahydroisoquinoline (Tic) scaffolds. Bioorg Med Chem Lett 20:1610-3 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Opioid receptors; mu & delta |
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| Name: | Opioid receptors; mu & delta |
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| Synonyms: | Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Voltage-gated potassium channel |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40465.04 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor. |
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| Residue: | 372 |
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| Sequence: | MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTAC
TPSDGPGGGAAA
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| BDBM50312854 |
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| n/a |
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| Name | BDBM50312854 |
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| Synonyms: | (S,3S,3'S)-N,N'-(ethane-1,2-diyl)bis(2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide) | CHEMBL1076736 |
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| Type | Small organic molecule |
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| Emp. Form. | C44H52N6O6 |
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| Mol. Mass. | 760.9203 |
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| SMILES | Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)NCCNC(=O)[C@@H]1Cc2ccccc2CN1C(=O)[C@@H](N)Cc1c(C)cc(O)cc1C |r| |
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| Structure | 
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