| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 |
|---|
| Ligand | BDBM50313297 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_617123 (CHEMBL1101381) |
|---|
| IC50 | 3±n/a nM |
|---|
| Citation |  Shah, U; Boyle, CD; Chackalamannil, S; Baker, H; Kowalski, T; Lee, J; Terracina, G; Zhang, L Azabicyclic sulfonamides as potent 11beta-HSD1 inhibitors. Bioorg Med Chem Lett20:1551-4 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 11-beta-hydroxysteroid dehydrogenase 1 |
|---|
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
|---|
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 32369.70 |
|---|
| Organism: | Mus musculus (mouse) |
|---|
| Description: | P50172 |
|---|
| Residue: | 292 |
|---|
| Sequence: | MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAH
VVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNH
ITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMI
APYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEE
CALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
|
|
|
|---|
| BDBM50313297 |
|---|
| n/a |
|---|
| Name | BDBM50313297 |
|---|
| Synonyms: | (1R,5S)-3-(4-tert-butylphenylsulfonyl)-8-cyclopentyl-3,8-diazabicyclo[3.2.1]octane | CHEMBL1082165 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H32N2O2S |
|---|
| Mol. Mass. | 376.556 |
|---|
| SMILES | CC(C)(C)c1ccc(cc1)S(=O)(=O)N1C[C@@H]2CC[C@H](C1)N2C1CCCC1 |r,TLB:10:13:20:17.16| |
|---|
| Structure | 
|
|---|
Search and Browse
