Reaction Details |
| Report a problem with these data |
Target | Sodium/glucose cotransporter 1 |
---|
Ligand | BDBM20880 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_617326 (CHEMBL1100948) |
---|
IC50 | 1200±n/a nM |
---|
Citation | Robinson, RP; Mascitti, V; Boustany-Kari, CM; Carr, CL; Foley, PM; Kimoto, E; Leininger, MT; Lowe, A; Klenotic, MK; Macdonald, JI; Maguire, RJ; Masterson, VM; Maurer, TS; Miao, Z; Patel, JD; Préville, C; Reese, MR; She, L; Steppan, CM; Thuma, BA; Zhu, T C-Aryl glycoside inhibitors of SGLT2: Exploration of sugar modifications including C-5 spirocyclization. Bioorg Med Chem Lett20:1569-72 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Sodium/glucose cotransporter 1 |
---|
Name: | Sodium/glucose cotransporter 1 |
Synonyms: | High affinity sodium-glucose cotransporter | NAGT | Na(+)/glucose cotransporter 1 | SC5A1_HUMAN | SGLT1 | SLC5A1 | Sodium-dependent glucose cotransporter 1 (SGLT1) | Sodium/glucose cotransporter 1 | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 1 |
Type: | Protein |
Mol. Mass.: | 73503.78 |
Organism: | Homo sapiens (Human) |
Description: | P13866 |
Residue: | 664 |
Sequence: | MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFL
AGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIY
IKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLA
IFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAI
PTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQR
CLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVG
CTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEK
ELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRV
NEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFIT
IVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKG
IFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCH
AYFA
|
|
|
BDBM20880 |
---|
n/a |
---|
Name | BDBM20880 |
Synonyms: | (2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl}-6-(hydroxymethyl)oxane-3,4,5-triol | BMS-512148 | C-aryl glucoside, 6 | CHEMBL429910 | Dapagliflozin |
Type | Small organic molecule |
Emp. Form. | C21H25ClO6 |
Mol. Mass. | 408.873 |
SMILES | CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |
Structure |
|