Reaction Details |
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Target | Neuropilin-1 |
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Ligand | BDBM50313487 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_617636 (CHEMBL1101245) |
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IC50 | 18000±n/a nM |
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Citation | Jarvis, A; Allerston, CK; Jia, H; Herzog, B; Garza-Garcia, A; Winfield, N; Ellard, K; Aqil, R; Lynch, R; Chapman, C; Hartzoulakis, B; Nally, J; Stewart, M; Cheng, L; Menon, M; Tickner, M; Djordjevic, S; Driscoll, PC; Zachary, I; Selwood, DL Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem53:2215-26 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neuropilin-1 |
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Name: | Neuropilin-1 |
Synonyms: | Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1 | NRP | NRP1 | NRP1_HUMAN | Neuropilin-1 | VEGF165R |
Type: | PROTEIN |
Mol. Mass.: | 103122.09 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_617636 |
Residue: | 923 |
Sequence: | MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA
PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF
IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVP
KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS
GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN
WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI
DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE
VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY
INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF
EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLV
DECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTF
CHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAH
CMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVI
FEGEIGKGNLGGIAVDDISINNHISQEDCAKPADLDKKNPEIKIDETGSTPGYEGEGEGD
KNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYN
FELVDGVKLKKDKLNTQSTYSEA
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BDBM50313487 |
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n/a |
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Name | BDBM50313487 |
Synonyms: | (S)-2-{[3-(4-Acetylamino-benzenesulfonylamino)-thiophene-2-carbonyl]-amino}-5-guanidino-pentanoic acid | CHEMBL1088744 |
Type | Small organic molecule |
Emp. Form. | C19H24N6O6S2 |
Mol. Mass. | 496.56 |
SMILES | [#6]-[#6](=O)-[#7]-c1ccc(cc1)S(=O)(=O)[#7]-c1ccsc1-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](-[#8])=O |r| |
Structure |
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