| Reaction Details |
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 | Report a problem with these data |
| Target | Neuropilin-1 |
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| Ligand | BDBM50313491 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_617640 (CHEMBL1101249) |
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| IC50 | 23000±n/a nM |
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| Citation |  Jarvis, A; Allerston, CK; Jia, H; Herzog, B; Garza-Garcia, A; Winfield, N; Ellard, K; Aqil, R; Lynch, R; Chapman, C; Hartzoulakis, B; Nally, J; Stewart, M; Cheng, L; Menon, M; Tickner, M; Djordjevic, S; Driscoll, PC; Zachary, I; Selwood, DL Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction. J Med Chem53:2215-26 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuropilin-1 |
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| Name: | Neuropilin-1 |
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| Synonyms: | Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1 | NRP | NRP1 | NRP1_HUMAN | Neuropilin-1 | VEGF165R |
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| Type: | PROTEIN |
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| Mol. Mass.: | 103122.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_617636 |
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| Residue: | 923 |
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| Sequence: | MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQA
PDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLF
IKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVP
KMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSS
GILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN
WSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKI
DVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFE
VYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSY
INEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSF
EGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLV
DECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTF
CHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAH
CMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVI
FEGEIGKGNLGGIAVDDISINNHISQEDCAKPADLDKKNPEIKIDETGSTPGYEGEGEGD
KNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYN
FELVDGVKLKKDKLNTQSTYSEA
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| BDBM50313491 |
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| n/a |
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| Name | BDBM50313491 |
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| Synonyms: | (S)-2-(3-(benzo[c][1,2,5]thiadiazole-4-sulfonamido)thiophene-2-carboxamido)-5-guanidinopentanoic acid | CHEMBL1078974 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19N7O5S3 |
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| Mol. Mass. | 497.572 |
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| SMILES | [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6@H](-[#7]-[#6](=O)-c1sccc1-[#7]S(=O)(=O)c1cccc2nsnc12)-[#6](-[#8])=O |r| |
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| Structure | 
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