| Reaction Details |
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 | Report a problem with these data |
| Target | Bombesin receptor subtype-3 |
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| Ligand | BDBM50313736 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_614787 (CHEMBL1113306) |
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| EC50 | 159±n/a nM |
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| Citation |  He, S; Dobbelaar, PH; Liu, J; Jian, T; Sebhat, IK; Lin, LS; Goodman, A; Guo, C; Guzzo, PR; Hadden, M; Henderson, AJ; Ruenz, M; Sargent, BJ; Yet, L; Kelly, TM; Palyha, O; Kan, Y; Pan, J; Chen, H; Marsh, DJ; Shearman, LP; Strack, AM; Metzger, JM; Feighner, SD; Tan, C; Howard, AD; Tamvakopoulos, C; Peng, Q; Guan, XM; Reitman, ML; Patchett, AA; Wyvratt, MJ; Nargund, RP Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists. Bioorg Med Chem Lett20:1913-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bombesin receptor subtype-3 |
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| Name: | Bombesin receptor subtype-3 |
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| Synonyms: | BRS-3 | BRS3 | BRS3_HUMAN | Bombesin 3 | Bombesin like receptor 3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44424.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Bombesin 3 BRS3 HUMAN::P32247 |
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| Residue: | 399 |
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| Sequence: | MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISV
GILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGC
KVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFAL
PEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLI
ARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQT
YVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADT
SLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF
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| BDBM50313736 |
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| n/a |
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| Name | BDBM50313736 |
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| Synonyms: | 4'-(2-(5-(3-fluorobenzyl)-1H-imidazol-2-yl)ethyl)biphenyl-2-carboxylic acid | CHEMBL1088614 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H21FN2O2 |
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| Mol. Mass. | 400.4448 |
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| SMILES | OC(=O)c1ccccc1-c1ccc(CCc2ncc(Cc3cccc(F)c3)[nH]2)cc1 |
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| Structure | 
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