| Reaction Details |
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 | Report a problem with these data |
| Target | Bombesin receptor subtype-3 |
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| Ligand | BDBM50313746 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_614790 (CHEMBL1113309) |
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| EC50 | 23±n/a nM |
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| Citation |  He, S; Dobbelaar, PH; Liu, J; Jian, T; Sebhat, IK; Lin, LS; Goodman, A; Guo, C; Guzzo, PR; Hadden, M; Henderson, AJ; Ruenz, M; Sargent, BJ; Yet, L; Kelly, TM; Palyha, O; Kan, Y; Pan, J; Chen, H; Marsh, DJ; Shearman, LP; Strack, AM; Metzger, JM; Feighner, SD; Tan, C; Howard, AD; Tamvakopoulos, C; Peng, Q; Guan, XM; Reitman, ML; Patchett, AA; Wyvratt, MJ; Nargund, RP Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists. Bioorg Med Chem Lett20:1913-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bombesin receptor subtype-3 |
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| Name: | Bombesin receptor subtype-3 |
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| Synonyms: | BRS3_MOUSE | Brs3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44239.49 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_1445902 |
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| Residue: | 399 |
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| Sequence: | MSQRQSQSPNQTLISITNDTETSSSVVSNDTTHKGWTGDNSPGIEALCAIYITYAGIISV
GILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGKVGC
KVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPPNAILKTCAKAGGIWIVSMIFAL
PEAIFSNVYTFQDPNRNVTFESCNSYPISERLLQEIHSLLCFLVFYIIPLSIISVYYSLI
ARTLYKSTLNIPTEEQSHARKQIESRKRIAKTVLVLVALFALCWLPNHLLYLYHSFTYES
YANHSDVPFVIIIFSRVLAFSNSCVNPFALYWLSKTFQQHFKAQLCCLKAEQPEPPLGDI
PLNNLTVMGRVPATGSAHVSEISVTLFSGSSAKKGEDKV
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| BDBM50313746 |
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| n/a |
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| Name | BDBM50313746 |
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| Synonyms: | 4'-(2-(5-((tetrahydro-2H-pyran-4-yl)methyl)-1H-imidazol-2-yl)ethyl)biphenyl-2-carboxylic acid | CHEMBL1097363 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N2O3 |
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| Mol. Mass. | 390.4748 |
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| SMILES | OC(=O)c1ccccc1-c1ccc(CCc2ncc(CC3CCOCC3)[nH]2)cc1 |
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| Structure | 
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