Reaction Details |
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Target | Disintegrin and metalloproteinase domain-containing protein 17 |
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Ligand | BDBM50313838 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_615262 (CHEMBL1115912) |
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Ki | 1.6±n/a nM |
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Citation | Yu, W; Guo, Z; Orth, P; Madison, V; Chen, L; Dai, C; Feltz, RJ; Girijavallabhan, VM; Kim, SH; Kozlowski, JA; Lavey, BJ; Li, D; Lundell, D; Niu, X; Piwinski, JJ; Popovici-Muller, J; Rizvi, R; Rosner, KE; Shankar, BB; Shih, NY; Siddiqui, MA; Sun, J; Tong, L; Umland, S; Wong, MK; Yang, DY; Zhou, G Discovery and SAR of hydantoin TACE inhibitors. Bioorg Med Chem Lett20:1877-80 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Disintegrin and metalloproteinase domain-containing protein 17 |
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Name: | Disintegrin and metalloproteinase domain-containing protein 17 |
Synonyms: | ADA17_HUMAN | ADAM17 | CSVP | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM-17) | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) | TACE | TNF-alpha convertase | TNF-alpha converting enzyme (TACE) | TNF-alpha-converting enzyme (TACE) | Tumor Necrosis Factor Alpha Converting Enzyme | Tumor necrosis factor-α converting enzyme (TACE) |
Type: | Enzyme |
Mol. Mass.: | 93007.89 |
Organism: | Homo sapiens (Human) |
Description: | |
Residue: | 824 |
Sequence: | MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDL
QTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVV
GEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQS
PKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMG
RGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNM
AKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGL
AECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGN
SRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSC
KVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLS
INTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMD
SASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKD
PFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC
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BDBM50313838 |
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n/a |
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Name | BDBM50313838 |
Synonyms: | (R)-5-(4-hydroxyphenyl)-5-((6-methoxy-1-oxoisoindolin-2-yl)methyl)imidazolidine-2,4-dione | CHEMBL1090736 |
Type | Small organic molecule |
Emp. Form. | C19H17N3O5 |
Mol. Mass. | 367.3554 |
SMILES | COc1ccc2CN(C[C@]3(NC(=O)NC3=O)c3ccc(O)cc3)C(=O)c2c1 |r| |
Structure |
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