Reaction Details |
| Report a problem with these data |
Target | Corticotropin-releasing factor receptor 1 |
---|
Ligand | BDBM50314022 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_615933 (CHEMBL1099779) |
---|
Ki | >5000±n/a nM |
---|
Citation | Vrudhula, VM; Dasgupta, B; Pin, SS; Burris, KD; Balanda, LA; Fung, LK; Fiedler, T; Browman, KE; Taber, MT; Zhang, J; Macor, JE; Dubowchik, GM Design, synthesis and evaluation of constrained tetrahydroimidazopyrimidine derivatives as antagonists of corticotropin-releasing factor type 1 receptor (CRF1R). Bioorg Med Chem Lett20:1905-9 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Corticotropin-releasing factor receptor 1 |
---|
Name: | Corticotropin-releasing factor receptor 1 |
Synonyms: | CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1 |
Type: | Enzyme |
Mol. Mass.: | 50744.31 |
Organism: | Homo sapiens (Human) |
Description: | P34998 |
Residue: | 444 |
Sequence: | MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPA
GQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAV
IINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLR
NIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGC
YLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYI
YQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFF
VNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARV
ARAMSIPTSPTRVSFHSIKQSTAV
|
|
|
BDBM50314022 |
---|
n/a |
---|
Name | BDBM50314022 |
Synonyms: | 8-mesityl-3-((4-methyl-1,4-diazepan-1-yl)methyl)-2-(trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine | CHEMBL1087299 |
Type | Small organic molecule |
Emp. Form. | C23H32F3N5 |
Mol. Mass. | 435.5289 |
SMILES | CN1CCCN(Cc2c(nc3N(CCCn23)c2c(C)cc(C)cc2C)C(F)(F)F)CC1 |
Structure |
|