Found 121 hits with Last Name = 'fung' and Initial = 'lk' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50058163
(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)Show SMILES CCCCN(CC)c1nc(C)nc2n(cc(C)c12)-c1c(C)cc(C)cc1C |(-10.62,2.69,;-9.29,3.46,;-7.95,2.7,;-6.62,3.48,;-5.28,2.71,;-3.95,3.49,;-3.96,5.03,;-5.27,1.17,;-6.6,.4,;-6.6,-1.14,;-7.94,-1.91,;-5.27,-1.91,;-3.92,-1.14,;-2.44,-1.61,;-1.54,-.35,;-2.46,.9,;-1.99,2.37,;-3.93,.41,;-1.96,-3.07,;-2.99,-4.22,;-4.49,-3.91,;-2.5,-5.68,;-.99,-5.99,;-.51,-7.46,;.03,-4.83,;-.46,-3.38,;.56,-2.22,)| Show InChI InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50058163
(Butyl-[2,5-dimethyl-7-(2,4,6-trimethyl-phenyl)-7H-...)Show SMILES CCCCN(CC)c1nc(C)nc2n(cc(C)c12)-c1c(C)cc(C)cc1C |(-10.62,2.69,;-9.29,3.46,;-7.95,2.7,;-6.62,3.48,;-5.28,2.71,;-3.95,3.49,;-3.96,5.03,;-5.27,1.17,;-6.6,.4,;-6.6,-1.14,;-7.94,-1.91,;-5.27,-1.91,;-3.92,-1.14,;-2.44,-1.61,;-1.54,-.35,;-2.46,.9,;-1.99,2.37,;-3.93,.41,;-1.96,-3.07,;-2.99,-4.22,;-4.49,-3.91,;-2.5,-5.68,;-.99,-5.99,;-.51,-7.46,;.03,-4.83,;-.46,-3.38,;.56,-2.22,)| Show InChI InChI=1S/C23H32N4/c1-8-10-11-26(9-2)22-20-18(6)14-27(23(20)25-19(7)24-22)21-16(4)12-15(3)13-17(21)5/h12-14H,8-11H2,1-7H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169540
(CHEMBL186479 | Cyclopropylmethyl-(2,2,2-trifluoro-...)Show SMILES Cc1cc(C)c(c(C)c1)-n1c2ccccc2n2c(CN(CC3CC3)CC(F)(F)F)c(nc12)C(F)(F)F |(8.33,-9.37,;7.25,-8.27,;5.76,-8.66,;4.67,-7.56,;3.19,-7.93,;5.09,-6.08,;6.58,-5.7,;6.98,-4.2,;7.65,-6.78,;4.02,-5,;4.27,-3.47,;5.57,-2.64,;5.5,-1.1,;4.13,-.4,;2.83,-1.22,;2.9,-2.76,;1.8,-3.83,;.26,-4.06,;-.81,-2.97,;-.4,-1.48,;1.08,-1.1,;1.49,.39,;2.59,1.46,;1.1,1.86,;-1.48,-.38,;-1.07,1.11,;-.69,2.46,;.4,1.76,;-2,2.42,;.01,-5.59,;1.38,-6.3,;2.49,-5.22,;-1.37,-6.28,;-2.84,-5.62,;-1.72,-7.84,;-2.63,-6.91,)| Show InChI InChI=1S/C26H26F6N4/c1-15-10-16(2)22(17(3)11-15)36-20-7-5-4-6-19(20)35-21(23(26(30,31)32)33-24(35)36)13-34(12-18-8-9-18)14-25(27,28)29/h4-7,10-11,18H,8-9,12-14H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 7.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity for human corticotropin releasing factor receptor 1 |
Bioorg Med Chem Lett 15: 4029-32 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.028
BindingDB Entry DOI: 10.7270/Q2B27TS9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50314008
(CHEMBL1087165 | N-(cyclopropylmethyl)-2,2,2-triflu...)Show SMILES Cc1cc(C)c(N2CCCn3c(CN(CC4CC4)CC(F)(F)F)c(nc23)C(F)(F)F)c(C)c1 Show InChI InChI=1S/C23H28F6N4/c1-14-9-15(2)19(16(3)10-14)33-8-4-7-32-18(20(23(27,28)29)30-21(32)33)12-31(11-17-5-6-17)13-22(24,25)26/h9-10,17H,4-8,11-13H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells |
Bioorg Med Chem Lett 20: 1905-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169535
(CHEMBL363592 | Dipropyl-[2-trifluoromethyl-9-(2,4,...)Show SMILES Cc1cc(C)c(c(C)c1)-n1c2ccccc2n2c(CN(CC3CC3)CC3CC3)c(nc12)C(F)(F)F |(15.58,-10,;14.49,-8.9,;14.91,-7.41,;13.83,-6.32,;14.24,-4.84,;12.35,-6.71,;11.93,-8.2,;10.44,-8.58,;13,-9.29,;11.28,-5.62,;11.53,-4.11,;12.82,-3.27,;12.75,-1.73,;11.37,-1.03,;10.09,-1.86,;10.16,-3.38,;9.06,-4.47,;7.53,-4.69,;6.45,-3.59,;6.85,-2.12,;8.34,-1.73,;8.74,-.24,;9.83,.84,;8.34,1.25,;5.78,-1.01,;6.18,.47,;5.78,1.96,;7.27,1.55,;7.27,-6.23,;8.65,-6.94,;9.74,-5.85,;5.89,-6.9,;4.64,-7.53,;4.42,-6.25,;5.53,-8.48,)| Show InChI InChI=1S/C28H31F3N4/c1-17-12-18(2)25(19(3)13-17)35-23-7-5-4-6-22(23)34-24(26(28(29,30)31)32-27(34)35)16-33(14-20-8-9-20)15-21-10-11-21/h4-7,12-13,20-21H,8-11,14-16H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity for human corticotropin releasing factor receptor 1 |
Bioorg Med Chem Lett 15: 4029-32 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.028
BindingDB Entry DOI: 10.7270/Q2B27TS9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169517
(CHEMBL190745 | Cyclopropylmethyl-[2-trifluoromethy...)Show SMILES Cc1cc(C)c(c(C)c1)-n1c2ccccc2n2c(CN(CCC(F)(F)F)CC3CC3)c(nc12)C(F)(F)F |(5.88,-11.87,;4.79,-10.77,;5.21,-9.28,;4.13,-8.18,;4.54,-6.71,;2.65,-8.58,;2.23,-10.07,;.73,-10.44,;3.3,-11.17,;1.57,-7.48,;1.82,-5.96,;3.11,-5.14,;3.04,-3.6,;1.67,-2.88,;.38,-3.72,;.45,-5.25,;-.65,-6.33,;-2.19,-6.56,;-3.27,-5.46,;-2.86,-3.98,;-3.94,-2.87,;-3.54,-1.39,;-4.61,-.29,;-5.6,.72,;-4.43,1.32,;-6.21,-.43,;-1.37,-3.58,;-.97,-2.1,;-1.35,-.61,;.12,-1.03,;-2.44,-8.09,;-1.07,-8.81,;.03,-7.71,;-3.83,-8.78,;-4.19,-10.35,;-5.08,-9.41,;-5.3,-8.11,)| Show InChI InChI=1S/C27H28F6N4/c1-16-12-17(2)23(18(3)13-16)37-21-7-5-4-6-20(21)36-22(24(27(31,32)33)34-25(36)37)15-35(14-19-8-9-19)11-10-26(28,29)30/h4-7,12-13,19H,8-11,14-15H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 13 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity for human corticotropin releasing factor receptor 1 |
Bioorg Med Chem Lett 15: 4029-32 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.028
BindingDB Entry DOI: 10.7270/Q2B27TS9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50314009
(CHEMBL1087166 | N-(cyclopropylmethyl)-2,2,3,3,3-pe...)Show SMILES Cc1cc(C)c(N2CCCn3c(CN(CC4CC4)CC(F)(F)C(F)(F)F)c(nc23)C(F)(F)F)c(C)c1 Show InChI InChI=1S/C24H28F8N4/c1-14-9-15(2)19(16(3)10-14)36-8-4-7-35-18(20(23(27,28)29)33-21(35)36)12-34(11-17-5-6-17)13-22(25,26)24(30,31)32/h9-10,17H,4-8,11-13H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells |
Bioorg Med Chem Lett 20: 1905-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50314010
(CHEMBL1087167 | N,N-diallyl-8-mesityl-2-(trifluoro...)Show SMILES Cc1cc(C)c(N2CCCn3c2nc(c3C(=O)N(CC=C)CC=C)C(F)(F)F)c(C)c1 Show InChI InChI=1S/C23H27F3N4O/c1-6-9-28(10-7-2)21(31)19-20(23(24,25)26)27-22-29(11-8-12-30(19)22)18-16(4)13-15(3)14-17(18)5/h6-7,13-14H,1-2,8-12H2,3-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells |
Bioorg Med Chem Lett 20: 1905-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169508
(CHEMBL424812 | Cyclopropylmethyl-[2-methyl-9-(2,4,...)Show SMILES CCCN(CC1CC1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 |(-9.52,5.06,;-8.46,3.94,;-8.86,2.47,;-7.77,1.35,;-6.29,1.74,;-5.88,3.24,;-4.78,4.31,;-6.27,4.71,;-8.18,-.12,;-7.11,-1.22,;-7.37,-2.76,;-8.74,-3.44,;-5.99,-3.48,;-4.88,-2.39,;-3.35,-2.15,;-2.28,-3.25,;-2.68,-4.74,;-4.18,-5.12,;-1.61,-5.83,;-.12,-5.44,;.96,-6.54,;.29,-3.95,;-.79,-2.85,;-.39,-1.38,;-3.1,-.64,;-1.8,.2,;-1.87,1.74,;-3.24,2.44,;-4.54,1.61,;-4.47,.09,;-5.57,-1,)| Show InChI InChI=1S/C27H34N4/c1-6-13-29(16-22-11-12-22)17-25-21(5)28-27-30(25)23-9-7-8-10-24(23)31(27)26-19(3)14-18(2)15-20(26)4/h7-10,14-15,22H,6,11-13,16-17H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity for human corticotropin releasing factor receptor 1 |
Bioorg Med Chem Lett 15: 4029-32 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.028
BindingDB Entry DOI: 10.7270/Q2B27TS9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50054245
(5-Chloro-N-cyclopropylmethyl-2-methyl-N-propyl-N''...)Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Cl Show InChI InChI=1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50054245
(5-Chloro-N-cyclopropylmethyl-2-methyl-N-propyl-N''...)Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Cl Show InChI InChI=1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50314011
(CHEMBL1088478 | N-(cyclobutylmethyl)-N-((8-mesityl...)Show SMILES CCCN(CC1CCC1)Cc1c(nc2N(CCCn12)c1c(C)cc(C)cc1C)C(F)(F)F Show InChI InChI=1S/C25H35F3N4/c1-5-10-30(15-20-8-6-9-20)16-21-23(25(26,27)28)29-24-31(21)11-7-12-32(24)22-18(3)13-17(2)14-19(22)4/h13-14,20H,5-12,15-16H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells |
Bioorg Med Chem Lett 20: 1905-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169531
(CHEMBL188523 | Cyclopropylmethyl-[2-ethyl-9-(2,4,6...)Show SMILES CCCN(CC1CC1)Cc1c(CC)nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12 |(-9.52,5.06,;-8.46,3.94,;-8.86,2.47,;-7.77,1.35,;-6.29,1.74,;-5.88,3.24,;-4.78,4.31,;-6.27,4.71,;-8.18,-.12,;-7.11,-1.22,;-7.37,-2.76,;-8.74,-3.44,;-10.03,-2.6,;-5.99,-3.48,;-4.88,-2.39,;-3.35,-2.16,;-2.28,-3.25,;-2.68,-4.74,;-4.18,-5.12,;-1.61,-5.83,;-.12,-5.45,;.96,-6.54,;.29,-3.95,;-.79,-2.86,;-.39,-1.38,;-3.1,-.64,;-1.8,.2,;-1.87,1.74,;-3.24,2.44,;-4.54,1.61,;-4.47,.09,;-5.57,-1,)| Show InChI InChI=1S/C28H36N4/c1-6-14-30(17-22-12-13-22)18-26-23(7-2)29-28-31(26)24-10-8-9-11-25(24)32(28)27-20(4)15-19(3)16-21(27)5/h8-11,15-16,22H,6-7,12-14,17-18H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity for human corticotropin releasing factor receptor 1 |
Bioorg Med Chem Lett 15: 4029-32 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.028
BindingDB Entry DOI: 10.7270/Q2B27TS9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169524
(CHEMBL186628 | Cyclopropylmethyl-propyl-[2-trifluo...)Show SMILES CCCN(CC1CC1)Cc1c(nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)C(F)(F)F |(-2.56,-11.8,;-1.49,-12.89,;-1.88,-14.38,;-.81,-15.48,;.68,-15.09,;1.08,-13.61,;.7,-12.12,;2.18,-12.53,;-1.21,-16.97,;-.13,-18.07,;-.39,-19.59,;.99,-20.32,;2.09,-19.22,;3.63,-19,;4.7,-20.08,;6.19,-19.7,;6.59,-18.21,;7.27,-20.78,;6.85,-22.28,;7.94,-23.37,;5.35,-22.67,;4.28,-21.58,;2.79,-21.95,;3.86,-17.47,;5.17,-16.64,;5.1,-15.1,;3.72,-14.39,;2.44,-15.23,;2.51,-16.76,;1.4,-17.84,;-1.77,-20.28,;-3.03,-20.91,;-3.24,-19.61,;-2.14,-21.86,)| Show InChI InChI=1S/C27H31F3N4/c1-5-12-32(15-20-10-11-20)16-23-25(27(28,29)30)31-26-33(23)21-8-6-7-9-22(21)34(26)24-18(3)13-17(2)14-19(24)4/h6-9,13-14,20H,5,10-12,15-16H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 23 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity for human corticotropin releasing factor receptor 1 |
Bioorg Med Chem Lett 15: 4029-32 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.028
BindingDB Entry DOI: 10.7270/Q2B27TS9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169569
(7-(2,4-Dichloro-6-methyl-phenyl)-2-ethyl-6,7-dihyd...)Show SMILES CCc1nc2N(CCn2c1C(=O)N(CC1CC1)CC(F)(F)F)c1c(C)cc(Cl)cc1Cl Show InChI InChI=1S/C21H23Cl2F3N4O/c1-3-16-18(19(31)28(10-13-4-5-13)11-21(24,25)26)30-7-6-29(20(30)27-16)17-12(2)8-14(22)9-15(17)23/h8-9,13H,3-7,10-11H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169520
(CHEMBL188813 | Cyclobutylmethyl-propyl-[2-trifluor...)Show SMILES CCCN(CC1CCC1)Cc1c(nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)C(F)(F)F |(-6.5,-3.36,;-5.43,-4.46,;-5.84,-5.95,;-4.76,-7.05,;-3.28,-6.67,;-2.87,-5.18,;-1.53,-4.43,;-2.3,-3.08,;-3.63,-3.85,;-5.17,-8.54,;-4.09,-9.63,;-4.35,-11.17,;-2.98,-11.87,;-1.86,-10.79,;-.34,-10.57,;.73,-11.65,;2.22,-11.27,;2.62,-9.77,;3.29,-12.35,;2.89,-13.85,;3.97,-14.94,;1.4,-14.23,;.33,-13.13,;-1.17,-13.52,;-.09,-9.04,;1.21,-8.21,;1.14,-6.67,;-.23,-5.97,;-1.53,-6.79,;-1.46,-8.33,;-2.56,-9.4,;-5.73,-11.85,;-6.98,-12.48,;-7.19,-11.19,;-6.08,-13.41,)| Show InChI InChI=1S/C28H33F3N4/c1-5-13-33(16-21-9-8-10-21)17-24-26(28(29,30)31)32-27-34(24)22-11-6-7-12-23(22)35(27)25-19(3)14-18(2)15-20(25)4/h6-7,11-12,14-15,21H,5,8-10,13,16-17H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity for human corticotropin releasing factor receptor 1 |
Bioorg Med Chem Lett 15: 4029-32 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.028
BindingDB Entry DOI: 10.7270/Q2B27TS9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169563
(7-(2-Bromo-4,6-dimethyl-phenyl)-2-ethyl-6,7-dihydr...)Show SMILES CCc1nc2N(CCn2c1C(=O)N(CC1CC1)CC(F)(F)F)c1c(C)cc(C)cc1Br Show InChI InChI=1S/C22H26BrF3N4O/c1-4-17-19(20(31)28(11-15-5-6-15)12-22(24,25)26)30-8-7-29(21(30)27-17)18-14(3)9-13(2)10-16(18)23/h9-10,15H,4-8,11-12H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50314012
(CHEMBL1088624 | N-(cyclobutylmethyl)-2,2,2-trifluo...)Show SMILES Cc1cc(C)c(N2CCCn3c(CN(CC4CCC4)CC(F)(F)F)c(nc23)C(F)(F)F)c(C)c1 Show InChI InChI=1S/C24H30F6N4/c1-15-10-16(2)20(17(3)11-15)34-9-5-8-33-19(21(24(28,29)30)31-22(33)34)13-32(14-23(25,26)27)12-18-6-4-7-18/h10-11,18H,4-9,12-14H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells |
Bioorg Med Chem Lett 20: 1905-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169533
(CHEMBL365715 | Cyclopropylmethyl-ethyl-[2-trifluor...)Show SMILES CCN(CC1CC1)Cc1c(nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)C(F)(F)F |(-5.82,4.24,;-6.22,2.74,;-5.15,1.65,;-3.65,2.03,;-3.26,3.51,;-2.16,4.59,;-3.64,4.99,;-5.55,.16,;-4.47,-.94,;-4.73,-2.47,;-3.35,-3.18,;-2.25,-2.1,;-.71,-1.87,;.36,-2.96,;1.84,-2.57,;2.25,-1.08,;2.92,-3.66,;2.5,-5.15,;3.59,-6.25,;1.01,-5.53,;-.06,-4.44,;-1.55,-4.83,;-.47,-.35,;.82,.48,;.75,2.02,;-.62,2.73,;-1.9,1.9,;-1.83,.37,;-2.94,-.71,;-6.11,-3.16,;-7.36,-3.79,;-7.58,-2.49,;-6.47,-4.72,)| Show InChI InChI=1S/C26H29F3N4/c1-5-31(14-19-10-11-19)15-22-24(26(27,28)29)30-25-32(22)20-8-6-7-9-21(20)33(25)23-17(3)12-16(2)13-18(23)4/h6-9,12-13,19H,5,10-11,14-15H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity for human corticotropin releasing factor receptor 1 |
Bioorg Med Chem Lett 15: 4029-32 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.028
BindingDB Entry DOI: 10.7270/Q2B27TS9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50314013
(CHEMBL1088625 | N-(cyclopropylmethyl)-N-((8-mesity...)Show SMILES CCN(CC1CC1)Cc1c(nc2N(CCCn12)c1c(C)cc(C)cc1C)C(F)(F)F Show InChI InChI=1S/C23H31F3N4/c1-5-28(13-18-7-8-18)14-19-21(23(24,25)26)27-22-29(19)9-6-10-30(22)20-16(3)11-15(2)12-17(20)4/h11-12,18H,5-10,13-14H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells |
Bioorg Med Chem Lett 20: 1905-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50314007
(CHEMBL1087164 | N-(cyclopropylmethyl)-N-((8-mesity...)Show SMILES CCCN(CC1CC1)Cc1c(nc2N(CCCn12)c1c(C)cc(C)cc1C)C(F)(F)F Show InChI InChI=1S/C24H33F3N4/c1-5-9-29(14-19-7-8-19)15-20-22(24(25,26)27)28-23-30(20)10-6-11-31(23)21-17(3)12-16(2)13-18(21)4/h12-13,19H,5-11,14-15H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells |
Bioorg Med Chem Lett 20: 1905-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169523
(CHEMBL427527 | Cyclopropylmethyl-(2,2,3,3,3-pentaf...)Show SMILES Cc1cc(C)c(c(C)c1)-n1c2ccccc2n2c(CN(CC3CC3)CC(F)(F)C(F)(F)F)c(nc12)C(F)(F)F |(3.76,-7.28,;2.69,-6.18,;3.1,-4.69,;2.01,-3.61,;2.42,-2.13,;.54,-3.99,;.12,-5.49,;-1.37,-5.86,;1.2,-6.58,;-.54,-2.91,;-.3,-1.38,;1.01,-.56,;.94,.98,;-.44,1.69,;-1.72,.85,;-1.65,-.68,;-2.77,-1.76,;-4.29,-1.98,;-5.38,-.89,;-4.96,.6,;-3.47,.99,;-3.07,2.47,;-3.47,3.95,;-1.97,3.54,;-6.04,1.7,;-5.63,3.19,;-4.55,4.28,;-7.12,2.79,;-6.71,4.28,;-8.31,4.14,;-7.68,5.28,;-6.53,5.89,;-4.55,-3.5,;-3.17,-4.23,;-2.07,-3.13,;-5.94,-4.2,;-7.4,-3.53,;-6.29,-5.77,;-7.18,-4.82,)| Show InChI InChI=1S/C27H26F8N4/c1-15-10-16(2)22(17(3)11-15)39-20-7-5-4-6-19(20)38-21(23(26(30,31)32)36-24(38)39)13-37(12-18-8-9-18)14-25(28,29)27(33,34)35/h4-7,10-11,18H,8-9,12-14H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 34 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity for human corticotropin releasing factor receptor 1 |
Bioorg Med Chem Lett 15: 4029-32 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.028
BindingDB Entry DOI: 10.7270/Q2B27TS9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50314015
(2,2,2-trifluoro-N-((8-mesityl-2-(trifluoromethyl)-...)Show SMILES Cc1cc(C)c(N2CCCn3c(CN(CCc4ccccc4)CC(F)(F)F)c(nc23)C(F)(F)F)c(C)c1 Show InChI InChI=1S/C27H30F6N4/c1-18-14-19(2)23(20(3)15-18)37-12-7-11-36-22(24(27(31,32)33)34-25(36)37)16-35(17-26(28,29)30)13-10-21-8-5-4-6-9-21/h4-6,8-9,14-15H,7,10-13,16-17H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells |
Bioorg Med Chem Lett 20: 1905-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169584
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)Show SMILES CCc1nc2N(CCn2c1C(=O)N(CC1CC1)CC(F)(F)F)c1c(C)cc(C)cc1C Show InChI InChI=1S/C23H29F3N4O/c1-5-18-20(21(31)28(12-17-6-7-17)13-23(24,25)26)30-9-8-29(22(30)27-18)19-15(3)10-14(2)11-16(19)4/h10-11,17H,5-9,12-13H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169575
(7-(2-Chloro-4,6-dimethyl-phenyl)-2-ethyl-6,7-dihyd...)Show SMILES CCc1nc2N(CCn2c1C(=O)N(CC1CC1)CC(F)(F)F)c1c(C)cc(C)cc1Cl Show InChI InChI=1S/C22H26ClF3N4O/c1-4-17-19(20(31)28(11-15-5-6-15)12-22(24,25)26)30-8-7-29(21(30)27-17)18-14(3)9-13(2)10-16(18)23/h9-10,15H,4-8,11-12H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169559
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)Show SMILES CCCN(CC1CC1)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C Show InChI InChI=1S/C24H34N4O/c1-6-10-26(15-19-8-9-19)23(29)22-20(7-2)25-24-27(11-12-28(22)24)21-17(4)13-16(3)14-18(21)5/h13-14,19H,6-12,15H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 42 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50314016
(CHEMBL1077156 | N-((8-mesityl-2-(trifluoromethyl)-...)Show SMILES CCCN(CC=C)Cc1c(nc2N(CCCn12)c1c(C)cc(C)cc1C)C(F)(F)F Show InChI InChI=1S/C23H31F3N4/c1-6-9-28(10-7-2)15-19-21(23(24,25)26)27-22-29(19)11-8-12-30(22)20-17(4)13-16(3)14-18(20)5/h6,13-14H,1,7-12,15H2,2-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 48 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells |
Bioorg Med Chem Lett 20: 1905-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169498
(CHEMBL191052 | Cyclobutylmethyl-(2,2,2-trifluoro-e...)Show SMILES Cc1cc(C)c(c(C)c1)-n1c2ccccc2n2c(CN(CC3CCC3)CC(F)(F)F)c(nc12)C(F)(F)F |(6.59,-23.74,;5.51,-22.63,;4.01,-23.02,;2.94,-21.93,;1.45,-22.32,;3.36,-20.45,;4.85,-20.06,;5.25,-18.57,;5.92,-21.15,;2.29,-19.36,;2.54,-17.84,;3.83,-17.01,;3.76,-15.48,;2.38,-14.77,;1.1,-15.59,;1.17,-17.13,;.07,-18.2,;-1.46,-18.43,;-2.54,-17.34,;-2.14,-15.85,;-.64,-15.47,;-.25,-13.98,;-1,-12.66,;.33,-11.89,;1.09,-13.23,;-3.21,-14.75,;-2.81,-13.26,;-2.42,-11.91,;-3.73,-11.96,;-1.48,-14.03,;-1.72,-19.96,;-.34,-20.67,;.75,-19.59,;-3.1,-20.65,;-4.57,-19.99,;-3.46,-22.21,;-4.35,-21.28,)| Show InChI InChI=1S/C27H28F6N4/c1-16-11-17(2)23(18(3)12-16)37-21-10-5-4-9-20(21)36-22(24(27(31,32)33)34-25(36)37)14-35(15-26(28,29)30)13-19-7-6-8-19/h4-5,9-12,19H,6-8,13-15H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 53 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity for human corticotropin releasing factor receptor 1 |
Bioorg Med Chem Lett 15: 4029-32 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.028
BindingDB Entry DOI: 10.7270/Q2B27TS9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169537
(CHEMBL191366 | [9-(2-Bromo-4-isopropyl-phenyl)-2-t...)Show SMILES CC(C)c1ccc(c(Br)c1)-n1c2ccccc2n2c(CN(CC3CC3)CC3CC3)c(nc12)C(F)(F)F |(10.56,-7.98,;10.96,-6.49,;12.45,-6.11,;9.89,-5.39,;8.4,-5.79,;7.33,-4.69,;7.74,-3.2,;9.21,-2.82,;9.63,-1.34,;10.3,-3.9,;6.67,-2.12,;6.91,-.59,;8.21,.23,;8.14,1.77,;6.77,2.49,;5.48,1.65,;5.55,.12,;4.44,-.96,;2.91,-1.19,;1.83,-.09,;2.25,1.39,;1.17,2.49,;1.57,3.98,;2.67,5.05,;1.17,5.45,;3.73,1.79,;4.13,3.26,;5.23,4.35,;3.74,4.75,;2.66,-2.71,;4.03,-3.43,;5.14,-2.34,;1.27,-3.4,;.02,-4.03,;-.2,-2.74,;.92,-4.97,)| Show InChI InChI=1S/C28H30BrF3N4/c1-17(2)20-11-12-22(21(29)13-20)35-23-5-3-4-6-24(23)36-25(26(28(30,31)32)33-27(35)36)16-34(14-18-7-8-18)15-19-9-10-19/h3-6,11-13,17-19H,7-10,14-16H2,1-2H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity for human corticotropin releasing factor receptor 1 |
Bioorg Med Chem Lett 15: 4029-32 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.028
BindingDB Entry DOI: 10.7270/Q2B27TS9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169529
(CHEMBL360185 | Cyclopropylmethyl-[6-fluoro-2-methy...)Show SMILES CCCN(CC1CC1)Cc1c(C)nc2n(-c3c(C)cc(C)cc3C)c3ccc(F)cc3n12 |(3.81,5.27,;4.89,4.17,;4.49,2.68,;5.56,1.58,;7.06,1.98,;7.45,3.45,;8.55,4.53,;7.07,4.94,;5.16,.09,;6.24,-1,;5.98,-2.53,;4.6,-3.22,;7.36,-3.25,;8.46,-2.16,;10,-1.94,;11.07,-3.02,;12.56,-2.64,;12.96,-1.15,;13.64,-3.72,;13.22,-5.21,;14.31,-6.31,;11.73,-5.61,;10.65,-4.51,;9.16,-4.89,;10.25,-.4,;11.54,.42,;11.47,1.96,;10.09,2.68,;10.02,4.22,;8.81,1.84,;8.88,.3,;7.77,-.78,)| Show InChI InChI=1S/C27H33FN4/c1-6-11-30(15-21-7-8-21)16-25-20(5)29-27-31(25)24-14-22(28)9-10-23(24)32(27)26-18(3)12-17(2)13-19(26)4/h9-10,12-14,21H,6-8,11,15-16H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 59 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity for human corticotropin releasing factor receptor 1 |
Bioorg Med Chem Lett 15: 4029-32 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.028
BindingDB Entry DOI: 10.7270/Q2B27TS9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169576
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)Show SMILES CCCN(CC(F)(F)F)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C Show InChI InChI=1S/C22H29F3N4O/c1-6-8-27(13-22(23,24)25)20(30)19-17(7-2)26-21-28(9-10-29(19)21)18-15(4)11-14(3)12-16(18)5/h11-12H,6-10,13H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 61 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50314017
(3,3,3-trifluoro-N-((8-mesityl-2-(trifluoromethyl)-...)Show SMILES CCCN(CCC(F)(F)F)Cc1c(nc2N(CCCn12)c1c(C)cc(C)cc1C)C(F)(F)F Show InChI InChI=1S/C23H30F6N4/c1-5-8-31(11-7-22(24,25)26)14-18-20(23(27,28)29)30-21-32(18)9-6-10-33(21)19-16(3)12-15(2)13-17(19)4/h12-13H,5-11,14H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 63 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells |
Bioorg Med Chem Lett 20: 1905-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169589
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)Show SMILES CCc1nc2N(CCn2c1C(=O)N(CC1CC1)CC(F)(F)C(F)(F)F)c1c(C)cc(C)cc1C Show InChI InChI=1S/C24H29F5N4O/c1-5-18-20(21(34)31(12-17-6-7-17)13-23(25,26)24(27,28)29)33-9-8-32(22(33)30-18)19-15(3)10-14(2)11-16(19)4/h10-11,17H,5-9,12-13H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 63 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50314014
(CHEMBL1088626 | N-((8-mesityl-2-(trifluoromethyl)-...)Show SMILES CCCN(CCc1ccccc1)Cc1c(nc2N(CCCn12)c1c(C)cc(C)cc1C)C(F)(F)F Show InChI InChI=1S/C28H35F3N4/c1-5-13-33(16-12-23-10-7-6-8-11-23)19-24-26(28(29,30)31)32-27-34(24)14-9-15-35(27)25-21(3)17-20(2)18-22(25)4/h6-8,10-11,17-18H,5,9,12-16,19H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 67 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Research& Development
Curated by ChEMBL
| Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells |
Bioorg Med Chem Lett 20: 1905-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169579
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)Show SMILES CCc1nc2N(CCn2c1C(=O)N(CC1CC1)CC1CC1)c1c(C)cc(C)cc1C Show InChI InChI=1S/C25H34N4O/c1-5-21-23(24(30)27(14-19-6-7-19)15-20-8-9-20)29-11-10-28(25(29)26-21)22-17(3)12-16(2)13-18(22)4/h12-13,19-20H,5-11,14-15H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169526
(CHEMBL364002 | Propyl-[2-trifluoromethyl-9-(2,4,6-...)Show SMILES CCCN(CCC(F)(F)F)Cc1c(nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)C(F)(F)F |(-2.65,3.67,;-4.14,3.28,;-4.54,1.79,;-6.03,1.41,;-7.1,2.51,;-6.7,4,;-7.78,5.1,;-8.76,6.1,;-7.59,6.69,;-9.39,4.94,;-6.43,-.08,;-5.35,-1.17,;-5.61,-2.7,;-4.23,-3.41,;-3.14,-2.33,;-1.6,-2.11,;-.53,-3.19,;.96,-2.8,;1.36,-1.31,;2.04,-3.89,;1.62,-5.38,;2.7,-6.48,;.12,-5.76,;-.95,-4.67,;-2.44,-5.06,;-1.35,-.58,;-.06,.25,;-.13,1.79,;-1.51,2.49,;-2.79,1.67,;-2.72,.13,;-3.82,-.94,;-6.99,-3.39,;-7.36,-4.95,;-8.24,-4.02,;-8.46,-2.73,)| Show InChI InChI=1S/C26H28F6N4/c1-5-11-34(12-10-25(27,28)29)15-21-23(26(30,31)32)33-24-35(21)19-8-6-7-9-20(19)36(24)22-17(3)13-16(2)14-18(22)4/h6-9,13-14H,5,10-12,15H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 68 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity for human corticotropin releasing factor receptor 1 |
Bioorg Med Chem Lett 15: 4029-32 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.028
BindingDB Entry DOI: 10.7270/Q2B27TS9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169588
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)Show SMILES CCc1nc2N(CCn2c1C(=O)N(CCC(F)(F)F)CC1CC1)c1c(C)cc(C)cc1C Show InChI InChI=1S/C24H31F3N4O/c1-5-19-21(22(32)29(14-18-6-7-18)9-8-24(25,26)27)31-11-10-30(23(31)28-19)20-16(3)12-15(2)13-17(20)4/h12-13,18H,5-11,14H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 73 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169515
(CHEMBL189115 | Propyl-(2,2,2-trifluoro-ethyl)-[2-t...)Show SMILES CCCN(Cc1c(nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)C(F)(F)F)CC(F)(F)F |(-2.65,3.67,;-4.14,3.28,;-4.54,1.79,;-6.03,1.41,;-6.43,-.08,;-5.35,-1.17,;-5.61,-2.7,;-4.23,-3.41,;-3.14,-2.33,;-1.6,-2.11,;-.53,-3.19,;-.95,-4.67,;-2.44,-5.06,;.12,-5.76,;1.62,-5.38,;2.7,-6.48,;2.04,-3.89,;.96,-2.8,;1.36,-1.31,;-1.35,-.58,;-.06,.25,;-.13,1.79,;-1.51,2.49,;-2.79,1.67,;-2.72,.13,;-3.82,-.94,;-6.99,-3.39,;-8.46,-2.73,;-7.36,-4.95,;-8.24,-4.02,;-7.1,2.51,;-6.7,4,;-6.32,5.34,;-5.22,4.64,;-7.64,5.31,)| Show InChI InChI=1S/C25H26F6N4/c1-5-10-33(14-24(26,27)28)13-20-22(25(29,30)31)32-23-34(20)18-8-6-7-9-19(18)35(23)21-16(3)11-15(2)12-17(21)4/h6-9,11-12H,5,10,13-14H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity for human corticotropin releasing factor receptor 1 |
Bioorg Med Chem Lett 15: 4029-32 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.028
BindingDB Entry DOI: 10.7270/Q2B27TS9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169511
((2,2,3,3,3-Pentafluoro-propyl)-propyl-[2-trifluoro...)Show SMILES CCCN(Cc1c(nc2n(-c3c(C)cc(C)cc3C)c3ccccc3n12)C(F)(F)F)CC(F)(F)C(F)(F)F |(-2.7,3.33,;-4.19,2.93,;-4.59,1.45,;-6.08,1.06,;-6.5,-.43,;-5.41,-1.52,;-5.66,-3.05,;-4.29,-3.76,;-3.19,-2.68,;-1.65,-2.46,;-.58,-3.54,;.89,-3.15,;1.31,-1.66,;1.98,-4.24,;1.57,-5.73,;2.64,-6.83,;.08,-6.11,;-.99,-5.02,;-2.49,-5.41,;-1.41,-.93,;-.11,-.1,;-.18,1.44,;-1.55,2.14,;-2.84,1.32,;-2.77,-.22,;-3.88,-1.29,;-7.05,-3.74,;-8.52,-3.08,;-7.4,-5.3,;-8.31,-4.37,;-7.16,2.16,;-6.75,3.65,;-5.99,4.98,;-5.27,3.26,;-7.82,4.75,;-9.43,4.59,;-8.8,5.75,;-7.65,6.34,)| Show InChI InChI=1S/C26H26F8N4/c1-5-10-36(14-24(27,28)26(32,33)34)13-20-22(25(29,30)31)35-23-37(20)18-8-6-7-9-19(18)38(23)21-16(3)11-15(2)12-17(21)4/h6-9,11-12H,5,10,13-14H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity for human corticotropin releasing factor receptor 1 |
Bioorg Med Chem Lett 15: 4029-32 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.028
BindingDB Entry DOI: 10.7270/Q2B27TS9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169581
(7-(2,4-Dichloro-6-methyl-phenyl)-2-ethyl-6,7-dihyd...)Show SMILES CCCN(CC1CC1)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(Cl)cc1Cl Show InChI InChI=1S/C22H28Cl2N4O/c1-4-8-26(13-15-6-7-15)21(29)20-18(5-2)25-22-27(9-10-28(20)22)19-14(3)11-16(23)12-17(19)24/h11-12,15H,4-10,13H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 75 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169558
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)Show SMILES CCN(CC1CC1)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C Show InChI InChI=1S/C23H32N4O/c1-6-19-21(22(28)25(7-2)14-18-8-9-18)27-11-10-26(23(27)24-19)20-16(4)12-15(3)13-17(20)5/h12-13,18H,6-11,14H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 94 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169591
(7-(2-Chloro-4,6-dimethyl-phenyl)-2-ethyl-6,7-dihyd...)Show SMILES CCCN(CC1CC1)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1Cl Show InChI InChI=1S/C23H31ClN4O/c1-5-9-26(14-17-7-8-17)22(29)21-19(6-2)25-23-27(10-11-28(21)23)20-16(4)12-15(3)13-18(20)24/h12-13,17H,5-11,14H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 94 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169557
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)Show SMILES CCCN(CCC)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C Show InChI InChI=1S/C23H34N4O/c1-7-10-25(11-8-2)22(28)21-19(9-3)24-23-26(12-13-27(21)23)20-17(5)14-16(4)15-18(20)6/h14-15H,7-13H2,1-6H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169573
(7-(2-Bromo-4,6-dimethyl-phenyl)-2-ethyl-6,7-dihydr...)Show SMILES CCCN(CC1CC1)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1Br Show InChI InChI=1S/C23H31BrN4O/c1-5-9-26(14-17-7-8-17)22(29)21-19(6-2)25-23-27(10-11-28(21)23)20-16(4)12-15(3)13-18(20)24/h12-13,17H,5-11,14H2,1-4H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 126 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169507
(CHEMBL188194 | Diallyl-[2-trifluoromethyl-9-(2,4,6...)Show SMILES Cc1cc(C)c(c(C)c1)-n1c2ccccc2n2c(CN(CC=C)CC=C)c(nc12)C(F)(F)F |(2.55,-6.49,;1.48,-5.39,;-.02,-5.78,;-1.09,-4.69,;-2.58,-5.07,;-.68,-3.2,;.8,-2.8,;1.21,-1.33,;1.89,-3.9,;-1.75,-2.11,;-1.51,-.59,;-.2,.25,;-.27,1.79,;-1.65,2.49,;-2.94,1.65,;-2.87,.13,;-3.98,-.96,;-5.5,-1.17,;-6.59,-.08,;-6.17,1.4,;-4.69,1.79,;-4.28,3.28,;-2.79,3.66,;-7.26,2.51,;-6.85,4,;-7.92,5.08,;-5.76,-2.71,;-4.38,-3.43,;-3.28,-2.34,;-7.15,-3.39,;-8.39,-4.02,;-8.62,-2.74,;-7.5,-4.96,)| Show InChI InChI=1S/C26H27F3N4/c1-6-12-31(13-7-2)16-22-24(26(27,28)29)30-25-32(22)20-10-8-9-11-21(20)33(25)23-18(4)14-17(3)15-19(23)5/h6-11,14-15H,1-2,12-13,16H2,3-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 138 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity for human corticotropin releasing factor receptor 1 |
Bioorg Med Chem Lett 15: 4029-32 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.028
BindingDB Entry DOI: 10.7270/Q2B27TS9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169505
(CHEMBL189809 | [9-(2-Bromo-4-isopropyl-phenyl)-2-t...)Show SMILES CCCN(CC1CC1)Cc1c(nc2n(-c3ccc(cc3Br)C(C)C)c3ccccc3n12)C(F)(F)F |(4.91,3.42,;3.41,3.03,;3.02,1.56,;1.52,1.16,;.45,2.26,;.85,3.75,;1.94,4.82,;.47,5.23,;1.12,-.33,;2.2,-1.42,;1.94,-2.95,;3.32,-3.67,;4.42,-2.57,;5.96,-2.36,;7.03,-3.44,;6.61,-4.93,;7.68,-6.03,;9.18,-5.63,;9.6,-4.14,;8.52,-3.06,;8.92,-1.57,;10.27,-6.73,;11.76,-6.35,;9.85,-8.22,;6.21,-.82,;7.5,,;7.43,1.54,;6.05,2.26,;4.77,1.42,;4.84,-.12,;3.73,-1.2,;.56,-3.64,;-.69,-4.27,;-.91,-2.97,;.19,-5.21,)| Show InChI InChI=1S/C27H30BrF3N4/c1-4-13-33(15-18-9-10-18)16-24-25(27(29,30)31)32-26-34(22-7-5-6-8-23(22)35(24)26)21-12-11-19(17(2)3)14-20(21)28/h5-8,11-12,14,17-18H,4,9-10,13,15-16H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity for human corticotropin releasing factor receptor 1 |
Bioorg Med Chem Lett 15: 4029-32 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.028
BindingDB Entry DOI: 10.7270/Q2B27TS9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169509
(CHEMBL187940 | Cyclopropylmethyl-[2-ethyl-6-fluoro...)Show SMILES CCCN(CC1CC1)Cc1c(CC)nc2n(-c3c(C)cc(C)cc3C)c3ccc(F)cc3n12 |(3.81,5.27,;4.89,4.17,;4.49,2.68,;5.56,1.58,;7.06,1.98,;7.45,3.45,;8.55,4.53,;7.07,4.94,;5.16,.09,;6.24,-1,;5.98,-2.53,;4.6,-3.22,;4.5,-4.76,;7.36,-3.25,;8.46,-2.16,;10,-1.94,;11.07,-3.02,;12.56,-2.64,;12.96,-1.15,;13.64,-3.72,;13.22,-5.21,;14.31,-6.31,;11.72,-5.61,;10.65,-4.51,;9.16,-4.89,;10.25,-.4,;11.54,.42,;11.47,1.96,;10.09,2.68,;10.02,4.22,;8.81,1.84,;8.88,.3,;7.77,-.78,)| Show InChI InChI=1S/C28H35FN4/c1-6-12-31(16-21-8-9-21)17-26-23(7-2)30-28-32(26)25-15-22(29)10-11-24(25)33(28)27-19(4)13-18(3)14-20(27)5/h10-11,13-15,21H,6-9,12,16-17H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Binding affinity for human corticotropin releasing factor receptor 1 |
Bioorg Med Chem Lett 15: 4029-32 (2005)
Article DOI: 10.1016/j.bmcl.2005.06.028
BindingDB Entry DOI: 10.7270/Q2B27TS9 |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169578
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)Show SMILES CCCN(CCc1ccccc1)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C Show InChI InChI=1S/C28H36N4O/c1-6-14-30(15-13-23-11-9-8-10-12-23)27(33)26-24(7-2)29-28-31(16-17-32(26)28)25-21(4)18-20(3)19-22(25)5/h8-12,18-19H,6-7,13-17H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169593
(2-Ethyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H-...)Show SMILES CCCN(CCC(F)(F)F)C(=O)c1c(CC)nc2N(CCn12)c1c(C)cc(C)cc1C Show InChI InChI=1S/C23H31F3N4O/c1-6-9-28(10-8-23(24,25)26)21(31)20-18(7-2)27-22-29(11-12-30(20)22)19-16(4)13-15(3)14-17(19)5/h13-14H,6-12H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
Corticotropin-releasing factor receptor 1
(Homo sapiens (Human)) | BDBM50169585
(2-Methyl-7-(2,4,6-trimethyl-phenyl)-6,7-dihydro-5H...)Show SMILES CCCN(CC1CC1)C(=O)c1c(C)nc2N(CCn12)c1c(C)cc(C)cc1C Show InChI InChI=1S/C23H32N4O/c1-6-9-25(14-19-7-8-19)22(28)21-18(5)24-23-26(10-11-27(21)23)20-16(3)12-15(2)13-17(20)4/h12-13,19H,6-11,14H2,1-5H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description
Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells |
Bioorg Med Chem Lett 15: 3870-3 (2005)
Article DOI: 10.1016/j.bmcl.2005.05.117
BindingDB Entry DOI: 10.7270/Q269733T |
More data for this
Ligand-Target Pair | |
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