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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Platelet-derived growth factor receptor alpha | ||
| Ligand | BDBM50314776 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_627031 (CHEMBL1104513) | ||
| Kd | 1100±n/a nM | ||
| Citation |  Pettus, LH; Wurz, RP; Xu, S; Herberich, B; Henkle, B; Liu, Q; McBride, HJ; Mu, S; Plant, MH; Saris, CJ; Sherman, L; Wong, LM; Chmait, S; Lee, MR; Mohr, C; Hsieh, F; Tasker, AS Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase. J Med Chem53:2973-85 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Platelet-derived growth factor receptor alpha | |||
| Name: | Platelet-derived growth factor receptor alpha | ||
| Synonyms: | Alpha-type platelet-derived growth factor receptor | PDGFR2 | PDGFRA | PDGFRalpha | PGFRA_HUMAN | Platelet-derived growth factor receptor alpha (PDGFR-alpha) | Platelet-derived growth factor receptor alpha (PDGFRA) | Platelet-derived growth factor receptor, alpha polypeptid | RHEPDGFRA | ||
| Type: | Protein | ||
| Mol. Mass.: | 122633.38 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P16234 | ||
| Residue: | 1089 | ||
| Sequence: |
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| BDBM50314776 | |||
| n/a | |||
| Name | BDBM50314776 | ||
| Synonyms: | CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-5-yl)-4-methylbenzamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H20F2N4O2 | ||
| Mol. Mass. | 434.438 | ||
| SMILES | Cc1ccc(cc1-c1cc2cnn(-c3c(F)cccc3F)c2n(C)c1=O)C(=O)NC1CC1 |(1.2,-4.58,;-.13,-3.81,;-1.47,-4.58,;-2.8,-3.81,;-2.8,-2.27,;-1.47,-1.5,;-.14,-2.27,;1.2,-1.5,;2.53,-2.26,;3.86,-1.49,;5.33,-1.97,;6.23,-.72,;5.3,.54,;6.07,1.87,;7.56,1.95,;8.35,.6,;8.33,3.29,;7.49,4.58,;5.95,4.58,;5.29,3.22,;3.7,3.4,;3.86,.05,;2.53,.82,;2.53,2.36,;1.19,.04,;-.14,.81,;-4.14,-1.5,;-4.14,.04,;-5.47,-2.28,;-6.81,-1.51,;-8.35,-1.51,;-7.58,-.17,)| | ||
| Structure | 
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