| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine kinase 2, mitochondrial |
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| Ligand | BDBM50314835 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_627482 (CHEMBL1111768) |
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| IC50 | 230±n/a nM |
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| Citation |  Van Poecke, S; Negri, A; Gago, F; Van Daele, I; Solaroli, N; Karlsson, A; Balzarini, J; Van Calenbergh, S 3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase. J Med Chem53:2902-12 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine kinase 2, mitochondrial |
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| Name: | Thymidine kinase 2, mitochondrial |
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| Synonyms: | KITM_HUMAN | TK2 | Thymidine kinase, mitochondrial |
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| Type: | PROTEIN |
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| Mol. Mass.: | 31013.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1333885 |
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| Residue: | 265 |
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| Sequence: | MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIA
SGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDR
HTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIV
YLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHH
MERMLELFEQNRDRILTPENRKHCP
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| BDBM50314835 |
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| n/a |
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| Name | BDBM50314835 |
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| Synonyms: | 3'-(4-Butyl-1,2,3-triazol-1-yl)-3'-deoxy-beta-D-thymidine | CHEMBL1089805 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H23N5O4 |
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| Mol. Mass. | 349.3849 |
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| SMILES | CCCCc1cn(nn1)[C@H]1C[C@@H](O[C@@H]1CO)n1cc(C)c(=O)[nH]c1=O |r| |
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| Structure | 
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