| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Thymidine kinase 2, mitochondrial |
|---|
| Ligand | BDBM50206488 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_627487 (CHEMBL1111773) |
|---|
| IC50 | 6300±n/a nM |
|---|
| Citation |  Van Poecke, S; Negri, A; Gago, F; Van Daele, I; Solaroli, N; Karlsson, A; Balzarini, J; Van Calenbergh, S 3'-[4-Aryl-(1,2,3-triazol-1-yl)]-3'-deoxythymidine analogues as potent and selective inhibitors of human mitochondrial thymidine kinase. J Med Chem53:2902-12 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Thymidine kinase 2, mitochondrial |
|---|
| Name: | Thymidine kinase 2, mitochondrial |
|---|
| Synonyms: | KITM_HUMAN | TK2 | Thymidine kinase, mitochondrial |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 31013.50 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1333885 |
|---|
| Residue: | 265 |
|---|
| Sequence: | MLLWPLRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIA
SGKTTCLEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDR
HTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIV
YLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHH
MERMLELFEQNRDRILTPENRKHCP
|
|
|
|---|
| BDBM50206488 |
|---|
| n/a |
|---|
| Name | BDBM50206488 |
|---|
| Synonyms: | (2R,3S,4R,5R)-2-(5-(2-bromovinyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-yl octanoate | 1-(2'-O-octanoyl-beta-D-arabinofuranosyl)-5(E)-(2-bromovinyl)uracil | CHEMBL238635 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H27BrN2O7 |
|---|
| Mol. Mass. | 475.331 |
|---|
| SMILES | CCCCCCCC(=O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]1n1cc(C=CBr)c(=O)[nH]c1=O |w:22.23| |
|---|
| Structure | 
|
|---|
Search and Browse
