| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily A member 5 |
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| Ligand | BDBM50315583 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_627337 (CHEMBL1108889) |
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| IC50 | 284±n/a nM |
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| Citation |  Beshore, DC; Liverton, NJ; McIntyre, CJ; Claiborne, CF; Libby, B; Culberson, JC; Salata, JJ; Regan, CP; Lynch, JJ; Kiss, L; Spencer, RH; Kane, SA; White, RB; Yeh, S; Hartman, GD; Dinsmore, CJ Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel. Bioorg Med Chem Lett20:2493-6 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily A member 5 |
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| Name: | Potassium voltage-gated channel subfamily A member 5 |
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| Synonyms: | HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5 |
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| Type: | Enzyme |
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| Mol. Mass.: | 67222.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P22460 |
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| Residue: | 613 |
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| Sequence: | MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDA
DSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQ
RVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQ
SGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIF
EYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANG
SGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNII
DVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGL
QILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTT
VGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQG
TQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSL
YALCLDTSRETDL
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| BDBM50315583 |
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| n/a |
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| Name | BDBM50315583 |
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| Synonyms: | 2-phenyl-1,1-di(pyridin-3-yl)-2-(pyrrolidin-1-yl)ethanol | CHEMBL1089159 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23N3O |
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| Mol. Mass. | 345.4375 |
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| SMILES | OC(C(N1CCCC1)c1ccccc1)(c1cccnc1)c1cccnc1 |
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| Structure | 
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