| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 14 |
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| Ligand | BDBM50315877 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_624964 (CHEMBL1107087) |
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| IC50 | 1110±n/a nM |
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| Citation |  Luedtke, GR; Schinzel, K; Tan, X; Tester, RW; Nashashibi, I; Xu, YJ; Dugar, S; Levy, DE; Jung, J Amide-based inhibitors of p38alpha MAP kinase. Part 1: discovery of novel N-pyridyl amide lead molecules. Bioorg Med Chem Lett20:2556-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 14 |
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| Name: | Mitogen-activated protein kinase 14 |
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| Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 41286.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16539 |
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| Residue: | 360 |
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| Sequence: | MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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| BDBM50315877 |
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| n/a |
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| Name | BDBM50315877 |
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| Synonyms: | CHEMBL1090584 | N-(4-fluorobenzyl)-N-(2-((S)-1-phenylethylamino)pyridin-4-yl)-1,4,4a,8a-tetrahydroisoquinoline-2(3H)-carboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C30H31FN4O |
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| Mol. Mass. | 482.5917 |
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| SMILES | C[C@H](Nc1cc(ccn1)N(Cc1ccc(F)cc1)C(=O)N1CCC2C=CC=CC2C1)c1ccccc1 |r,c:26,28| |
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| Structure | 
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