| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP3 subtype |
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| Ligand | BDBM50315978 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_625742 (CHEMBL1104419) |
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| IC50 | 5.5±n/a nM |
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| Citation |  Asada, M; Obitsu, T; Kinoshita, A; Nakai, Y; Nagase, T; Sugimoto, I; Tanaka, M; Takizawa, H; Yoshikawa, K; Sato, K; Narita, M; Ohuchida, S; Nakai, H; Toda, M Discovery of novel N-acylsulfonamide analogs as potent and selective EP3 receptor antagonists. Bioorg Med Chem Lett20:2639-43 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E2 receptor EP3 subtype |
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| Name: | Prostaglandin E2 receptor EP3 subtype |
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| Synonyms: | PE2R3_MOUSE | PGE receptor, EP3 isoform alpha | Prostaglandin E2 receptor EP3 isoform alpha | Prostaglandin E3 | Prostanoid EP3 receptor | Ptger3 | Ptgerep3 |
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| Type: | G-protein coupled receptor |
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| Mol. Mass.: | 40092.50 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | n/a |
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| Residue: | 365 |
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| Sequence: | MASMWAPEHSAEAHSNLSSTTDDCGSVSVAFPITMMVTGFVGNALAMLLVSRSYRRRESK
RKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLS
SLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWP
GTWCFISTGPAGNETDPAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKA
AVSQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKE
CNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSALMWS
DQLER
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| BDBM50315978 |
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| n/a |
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| Name | BDBM50315978 |
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| Synonyms: | 3-(4-((1H-pyrazol-1-yl)methyl)-2-(2-(naphthalen-2-yl)ethoxy)phenyl)-N-(3-chloro-4-fluorophenylsulfonyl)propanamide | CHEMBL1091740 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H27ClFN3O4S |
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| Mol. Mass. | 592.08 |
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| SMILES | Fc1ccc(cc1Cl)S(=O)(=O)NC(=O)CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1 |
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| Structure | 
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