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TargetProstaglandin E2 receptor EP1 subtype
LigandBDBM50315979
Substrate/Competitorn/a
Meas. Tech.ChEMBL_625744 (CHEMBL1104421)
Ki 2100±n/a nM
Citation Asada, MObitsu, TKinoshita, ANakai, YNagase, TSugimoto, ITanaka, MTakizawa, HYoshikawa, KSato, KNarita, MOhuchida, SNakai, HToda, M Discovery of novel N-acylsulfonamide analogs as potent and selective EP3 receptor antagonists. Bioorg Med Chem Lett20:2639-43 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin E2 receptor EP1 subtype
Name:Prostaglandin E2 receptor EP1 subtype
Synonyms:PE2R1_MOUSE | PGE receptor, EP1 subtype | Prostaglandin E1 | Prostaglandin E2 receptor EP1 subtype | Prostanoid EP1 receptor | Ptger1 | Ptgerep1
Type:G-protein coupled receptor
Mol. Mass.:43000.62
Organism:Mus musculus (Mouse)
Description:n/a
Residue:405
Sequence:
MSPCGLNLSLADEAATCATPRLPNTSVVLPTGDNGTSPALPIFSMTLGAVSNVLALALLA
QVAGRMRRRRSAATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMV
FFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALAVLAAMALAVALLPLVHVGR
YELQYPGTWCFISLGPRGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRR
SRRFRKTAGPDDRRRWGSRGPRLASASSASSITSATATLRSSRGGGSARRVHAHDVEMVG
QLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQA
MLRQLLRLLPLRVSAKGGPTELGLTKSAWEASSLRSSRHSGFSHL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50315979
n/a
NameBDBM50315979
Synonyms:3-(4-((1H-pyrazol-1-yl)methyl)-2-(2-(naphthalen-2-yl)ethoxy)phenyl)-N-(3,4-difluorophenylsulfonyl)propanamide | CHEMBL1091741
TypeSmall organic molecule
Emp. Form.C31H27F2N3O4S
Mol. Mass.575.626
SMILESFc1ccc(cc1F)S(=O)(=O)NC(=O)CCc1ccc(Cn2cccn2)cc1OCCc1ccc2ccccc2c1
Structure
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