| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor 1 |
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| Ligand | BDBM50002368 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_627980 (CHEMBL1105501) |
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| EC50 | 1100±n/a nM |
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| Citation |  Fleming, JJ; England, PM Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. Bioorg Med Chem18:1381-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate receptor 1 |
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| Name: | Glutamate receptor 1 |
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| Synonyms: | AMPA-selective glutamate receptor 1 | GRIA1_RAT | GluA1 | GluR-1 | GluR-A | GluR-K1 | Glur1 | Glutamate receptor ionotropic, AMPA 1 | Gria1 |
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| Type: | Protein |
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| Mol. Mass.: | 101583.91 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P19490 |
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| Residue: | 907 |
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| Sequence: | MPYIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQID
IVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQ
FVLQLRPELQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTT
TEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDL
NKFKESGANVTGFQLVNYTDTIPARIMQQWRTSDSRDHTRVDWKRPKYTSALTYDGVKVM
AEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGR
RTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYV
MLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGE
LVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW
MCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQ
QGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIA
YGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLES
TMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKW
WYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMK
GFCLIPQQSINEAIRTSTLPRNSGAGASGGGGSGENGRVVSQDFPKSMQSIPCMSHSSGM
PLGATGL
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| BDBM50002368 |
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| n/a |
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| Name | BDBM50002368 |
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| Synonyms: | (R,S)-2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid | (S)-2-AMINO-3-(3-CARBOXY-5-METHYLISOXAZOL-4-YL)PROPIONIC ACID | 4-(2-Amino-2-carboxy-ethyl)-5-methyl-isoxazole-3-carboxylic acid | 4-(2-Amino-2-carboxy-ethyl)-5-methyl-isoxazole-3-carboxylic acid (ACPA) | 4-(2-amino-2-carboxyethyl)-5-methylisoxazole-3-carboxylic acid | ACPA | CHEMBL12442 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H10N2O5 |
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| Mol. Mass. | 214.1754 |
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| SMILES | Cc1onc(C(O)=O)c1CC(N)C(O)=O |
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| Structure | 
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