| Reaction Details |
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 | Report a problem with these data |
| Target | Polyphenol oxidase 2 |
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| Ligand | BDBM50068224 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_629402 (CHEMBL1105755) |
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| IC50 | 4800±n/a nM |
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| Citation |  Seo, WD; Ryu, YB; Curtis-Long, MJ; Lee, CW; Ryu, HW; Jang, KC; Park, KH Evaluation of anti-pigmentary effect of synthetic sulfonylamino chalcone. Eur J Med Chem45:2010-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyphenol oxidase 2 |
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| Name: | Polyphenol oxidase 2 |
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| Synonyms: | Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase |
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| Type: | Protein |
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| Mol. Mass.: | 63923.66 |
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| Organism: | Agaricus bisporus (Common mushroom) |
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| Description: | O42713 |
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| Residue: | 556 |
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| Sequence: | MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLP
FTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWV
QAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPY
GDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDD
QHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVW
VTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGG
TKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKK
FELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNH
YLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDH
TQARVVFDDVAVHVIN
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| BDBM50068224 |
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| n/a |
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| Name | BDBM50068224 |
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| Synonyms: | (E)-1,3-Bis-(4-hydroxy-phenyl)-propenone | 1,3-bis(4-hydroxyphenyl)prop-2-en-1-one | 4',4-Dihydroxychalcone | 4,4'-dihydroxychalcone | CHEMBL145927 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12O3 |
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| Mol. Mass. | 240.254 |
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| SMILES | Oc1ccc(\C=C\C(=O)c2ccc(O)cc2)cc1 |
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| Structure | 
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