| Reaction Details |
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 | Report a problem with these data |
| Target | Bombesin receptor subtype-3 |
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| Ligand | BDBM50316905 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_630081 (CHEMBL1110001) |
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| IC50 | 5.3±n/a nM |
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| Citation |  Hadden, M; Goodman, A; Guo, C; Guzzo, PR; Henderson, AJ; Pattamana, K; Ruenz, M; Sargent, BJ; Swenson, B; Yet, L; Liu, J; He, S; Sebhat, IK; Lin, LS; Tamvakopoulos, C; Peng, Q; Kan, Y; Palyha, O; Kelly, TM; Guan, XM; Metzger, JM; Reitman, ML; Nargund, RP Synthesis and SAR of heterocyclic carboxylic acid isosteres based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity. Bioorg Med Chem Lett20:2912-5 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bombesin receptor subtype-3 |
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| Name: | Bombesin receptor subtype-3 |
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| Synonyms: | BRS-3 | BRS3 | BRS3_HUMAN | Bombesin 3 | Bombesin like receptor 3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44424.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Bombesin 3 BRS3 HUMAN::P32247 |
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| Residue: | 399 |
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| Sequence: | MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISV
GILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGC
KVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFAL
PEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLI
ARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQT
YVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADT
SLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF
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| BDBM50316905 |
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| n/a |
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| Name | BDBM50316905 |
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| Synonyms: | (R)-1-(4-(2-(4-(2,2-dimethylbutyl)-1H-imidazol-2-yl)ethyl)phenyl)piperidine-2-carboxylic acid | CHEMBL1088409 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H33N3O2 |
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| Mol. Mass. | 383.527 |
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| SMILES | CCC(C)(C)Cc1cnc(CCc2ccc(cc2)N2CCCC[C@@H]2C(O)=O)[nH]1 |r| |
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| Structure | 
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