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TargetAdenosine receptor A1
LigandBDBM50317008
Substrate/Competitorn/a
Meas. Tech.ChEMBL_630131
Ki 0.5±n/a nM
Citation Shook BCRassnick SHall DRupert KCHeintzelman GRHansen KChakravarty DBullington JLScannevin RHMagliaro BWestover LCarroll KLampron LRussell RBranum SWells KDamon SYouells SLi XOsbourne MDemarest KTang YRhodes KJackson PF Methylene amine substituted arylindenopyrimidines as potent adenosine A(2A)/A(1) antagonists. Bioorg Med Chem Lett 20:2864-7 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Adenosine receptor A1
Name:Adenosine receptor A1/Alpha-2A adrenergic receptor
Synonyms:A1 adenosine receptor (hA1) | A1AR | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:36520.92
Organism:Homo sapiens (Human)
Description:P30542
Residue:326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD
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  Blast E-value cutoff:
BDBM50317008
n/a
NameBDBM50317008
Synonyms:2-amino-4-(5-chlorofuran-2-yl)-5H-indeno[1,2-d]pyrimidin-5-one | CHEMBL1097494
TypeSmall organic molecule
Emp. Form.C15H8ClN3O2
Mol. Mass.297.696
SMILESNc1nc2-c3ccccc3C(=O)c2c(n1)-c1ccc(Cl)o1
Structure
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