| Reaction Details |
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 | Report a problem with these data |
| Target | P2Y purinoceptor 4 |
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| Ligand | BDBM50319144 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_635652 (CHEMBL1119544) |
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| EC50 | 85±n/a nM |
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| Citation |  Maruoka, H; Barrett, MO; Ko, H; Tosh, DK; Melman, A; Burianek, LE; Balasubramanian, R; Berk, B; Costanzi, S; Harden, TK; Jacobson, KA Pyrimidine ribonucleotides with enhanced selectivity as P2Y(6) receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate gamma-ester modifications. J Med Chem53:4488-501 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2Y purinoceptor 4 |
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| Name: | P2Y purinoceptor 4 |
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| Synonyms: | NRU | P2P | P2RY4 | P2RY4_HUMAN | P2Y purinoceptor 4 | P2Y4 | Pyrimidinergic receptor P2Y4 | UNR | Uridine nucleotide receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40977.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_751027 |
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| Residue: | 365 |
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| Sequence: | MASTESSLLRSLGLSPGPGSSEVELDCWFDEDFKFILLPVSYAVVFVLGLGLNAPTLWLF
IFRLRPWDATATYMFHLALSDTLYVLSLPTLIYYYAAHNHWPFGTEICKFVRFLFYWNLY
CSVLFLTCISVHRYLGICHPLRALRWGRPRLAGLLCLAVWLVVAGCLVPNLFFVTTSNKG
TTVLCHDTTRPEEFDHYVHFSSAVMGLLFGVPCLVTLVCYGLMARRLYQPLPGSAQSSSR
LRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLEADCRVLNIVNVVYKVTRPLASANSC
LDPVLYLLTGDKYRRQLRQLCGGGKPQPRTAASSLALVSLPEDSSCRWAATPQDSSCSTP
RADRL
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| BDBM50319144 |
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| n/a |
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| Name | BDBM50319144 |
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| Synonyms: | ((1S,2S,4S,5S)-4-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-hydroxybicyclo[3.1.0]hexan-1-yl)methyl tetrahydrogen triphosphate | CHEMBL1083763 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H17N2O13P3 |
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| Mol. Mass. | 478.1796 |
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| SMILES | O[C@H]1C[C@@H]([C@H]2C[C@]12COP(O)(=O)OP(O)(=O)OP(O)(O)=O)n1ccc(=O)[nH]c1=O |r| |
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| Structure | 
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