| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 2 |
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| Ligand | BDBM23532 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_633970 (CHEMBL1117820) |
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| EC50 | 1300±n/a nM |
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| Citation |  Ding, FX; Shen, HC; Wilsie, LC; Krsmanovic, ML; Taggart, AK; Ren, N; Cai, TQ; Wang, J; Tong, X; Holt, TG; Chen, Q; Waters, MG; Hammond, ML; Tata, JR; Colletti, SL Discovery of pyrazolyl propionyl cyclohexenamide derivatives as full agonists for the high affinity niacin receptor GPR109A. Bioorg Med Chem Lett20:3372-5 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxycarboxylic acid receptor 2 |
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| Name: | Hydroxycarboxylic acid receptor 2 |
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| Synonyms: | G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 41868.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay. |
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| Residue: | 363 |
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| Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
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| BDBM23532 |
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| n/a |
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| Name | BDBM23532 |
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| Synonyms: | 2-{3-[1-(5-hydroxypyridin-2-yl)-1H-pyrazol-3-yl]propanamido}benzoic acid | Biaryl Anthranilide Analogue, 2n |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16N4O4 |
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| Mol. Mass. | 352.344 |
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| SMILES | OC(=O)c1ccccc1NC(=O)CCc1ccn(n1)-c1ccc(O)cn1 |
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| Structure | 
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