| Reaction Details |
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 | Report a problem with these data |
| Target | Thromboxane A2 receptor |
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| Ligand | BDBM50319491 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_634234 (CHEMBL1120181) |
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| Ki | 3400±n/a nM |
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| Citation |  Tumey, LN; Robarge, MJ; Gleason, E; Song, J; Murphy, SM; Ekema, G; Doucette, C; Hanniford, D; Palmer, M; Pawlowski, G; Danzig, J; Loftus, M; Hunady, K; Sherf, B; Mays, RW; Stricker-Krongrad, A; Brunden, KR; Bennani, YL; Harrington, JJ 3-Indolyl sultams as selective CRTh2 antagonists. Bioorg Med Chem Lett20:3287-90 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thromboxane A2 receptor |
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| Name: | Thromboxane A2 receptor |
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| Synonyms: | Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta |
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| Type: | Enyzme |
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| Mol. Mass.: | 37445.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21731 |
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| Residue: | 343 |
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| Sequence: | MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR
SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL
LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG
SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE
VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN
QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
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| BDBM50319491 |
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| n/a |
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| Name | BDBM50319491 |
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| Synonyms: | CHEMBL1083446 | rac-(3-{2-[2-(4-Chloro-phenoxy)-ethyl]-1,1-dioxo-2,3-dihydro-1H-1lambda*6*-benzo[d]isothiazol-3-yl}-2-methyl-indol-1-yl)-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C26H23ClN2O5S |
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| Mol. Mass. | 510.989 |
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| SMILES | Cc1c(C2N(CCOc3ccc(Cl)cc3)S(=O)(=O)c3ccccc23)c2ccccc2n1CC(O)=O |
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| Structure | 
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