| Reaction Details |
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 | Report a problem with these data |
| Target | Hexokinase-4 |
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| Ligand | BDBM50321004 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_639399 (CHEMBL1167931) |
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| EC50 | 26±n/a nM |
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| Citation |  Li, F; Zhu, Q; Zhang, Y; Feng, Y; Leng, Y; Zhang, A Design, synthesis, and pharmacological evaluation of N-(4-mono and 4,5-disubstituted thiazol-2-yl)-2-aryl-3-(tetrahydro-2H-pyran-4-yl)propanamides as glucokinase activators. Bioorg Med Chem18:3875-84 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hexokinase-4 |
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| Name: | Hexokinase-4 |
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| Synonyms: | Gck | HXK4_RAT | Hexokinase type IV |
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| Type: | PROTEIN |
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| Mol. Mass.: | 52101.81 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1279785 |
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| Residue: | 465 |
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| Sequence: | MLDDRARMEATKKEKVEQILAEFQLQEEDLKKVMSRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEAGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDLDKGILLNWTKGFKASGAEGNN
IVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDRQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRMVDESSANPGQQLYEKIIGGKYMGE
LVRLVLLKLVDENLLFHGEASEQLRTRGAFETRFVSQVESDSGDRKQIHNILSTLGLRPS
VTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPNCEITFIESEEGSGRGAALVSAVACKKACMLAQ
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| BDBM50321004 |
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| n/a |
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| Name | BDBM50321004 |
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| Synonyms: | (R)-2-(4-(Cyclopropylsulfonyl)phenyl)-N-(4-isopropylthiazol-2-yl)-3-(tetrahydro-2H-pyran-4-yl)propanamide | CHEMBL1165653 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H30N2O4S2 |
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| Mol. Mass. | 462.625 |
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| SMILES | CC(C)c1csc(NC(=O)[C@H](CC2CCOCC2)c2ccc(cc2)S(=O)(=O)C2CC2)n1 |r| |
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| Structure | 
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