| Reaction Details |
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 | Report a problem with these data |
| Target | Neuropeptide S receptor |
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| Ligand | BDBM50322834 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_644490 (CHEMBL1211328) |
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| IC50 | 31±n/a nM |
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| Citation |  Melamed, JY; Zartman, AE; Kett, NR; Gotter, AL; Uebele, VN; Reiss, DR; Condra, CL; Fandozzi, C; Lubbers, LS; Rowe, BA; McGaughey, GB; Henault, M; Stocco, R; Renger, JJ; Hartman, GD; Bilodeau, MT; Trotter, BW Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists. Bioorg Med Chem Lett20:4700-3 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuropeptide S receptor |
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| Name: | Neuropeptide S receptor |
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| Synonyms: | GPR154 | GPRA | NPSR1 | NPSR1_HUMAN | PGR14 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 42692.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1276607 |
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| Residue: | 371 |
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| Sequence: | MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLF
VFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLV
CRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIP
TLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIK
SKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFN
LLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERH
EMQILSKPEFI
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| BDBM50322834 |
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| n/a |
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| Name | BDBM50322834 |
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| Synonyms: | CHEMBL1210242 | N-((1-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-N-(2-methyl-4-(piperidin-1-yl)butan-2-yl)cyclohexanecarboxamide |
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| Type | Small organic molecule |
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| Emp. Form. | C28H41N3O2 |
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| Mol. Mass. | 451.644 |
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| SMILES | Cn1c2ccccc2cc(CN(C(=O)C2CCCCC2)C(C)(C)CCN2CCCCC2)c1=O |
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| Structure | 
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