Reaction Details | |||
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Target | Dipeptidyl peptidase 4 | ||
Ligand | BDBM50323175 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_643842 (CHEMBL1211741) | ||
Ki | 43±n/a nM | ||
Citation | Brigance, RP; Meng, W; Fura, A; Harrity, T; Wang, A; Zahler, R; Kirby, MS; Hamann, LG Synthesis and SAR of azolopyrimidines as potent and selective dipeptidyl peptidase-4 (DPP4) inhibitors for type 2 diabetes. Bioorg Med Chem Lett20:4395-8 (2010) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Dipeptidyl peptidase 4 | |||
Name: | Dipeptidyl peptidase 4 | ||
Synonyms: | ADABP | ADCP2 | Adenosine deaminase complexing protein 2 | CD26 | CD_antigen=CD26 | DPP IV | DPP4 | DPP4_HUMAN | DPPIV | Dipeptidyl peptidase 4 (DDP-IV) | Dipeptidyl peptidase 4 (DPP IV) | Dipeptidyl peptidase 4 (DPP-4) | Dipeptidyl peptidase 4 (DPP4) | Dipeptidyl peptidase 4 (DPPIV) | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV (DDP-4) | Dipeptidyl peptidase IV (DDP-IV) | Dipeptidyl peptidase IV (DPP IV) | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | Dipeptidyl peptidase-IV (DPP-4) | Dipeptidyl peptidase-IV (DPP-IV) | T-cell activation antigen CD26 | TP103 | ||
Type: | Enzyme | ||
Mol. Mass.: | 88271.01 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P27487 | ||
Residue: | 766 | ||
Sequence: |
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BDBM50323175 | |||
n/a | |||
Name | BDBM50323175 | ||
Synonyms: | (7-(2,4-dichlorophenyl)-2-(furan-2-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)methanamine | CHEMBL1209609 | ||
Type | Small organic molecule | ||
Emp. Form. | C18H14Cl2N4O | ||
Mol. Mass. | 373.236 | ||
SMILES | Cc1nc2cc(nn2c(c1CN)-c1ccc(Cl)cc1Cl)-c1ccco1 |(32.7,-8.42,;31.37,-9.2,;30.03,-8.43,;28.7,-9.2,;27.23,-8.74,;26.33,-9.99,;27.24,-11.23,;28.71,-10.75,;30.04,-11.51,;31.37,-10.74,;32.71,-11.5,;34.04,-10.73,;30.05,-13.04,;28.72,-13.81,;28.72,-15.36,;30.05,-16.13,;30.05,-17.67,;31.39,-15.36,;31.38,-13.81,;32.72,-13.03,;24.79,-10,;23.87,-8.77,;22.41,-9.26,;22.42,-10.8,;23.89,-11.26,)| | ||
Structure |